右美托咪定用于围脑干手术后带管的临床观察  

Clinical observation on dexmedetomidine on the patients with endotracheal tube after brain stemsurgery

作　　者：宁雪[1] 谭平[1] 尧永华[1] 

机构地区：[1]广州医学院附属肿瘤医院麻醉科,广州510095

出　　处：《国际医药卫生导报》2012年第10期1431-1433,共3页International Medicine and Health Guidance News

摘　　要：目的研究右美托咪定用于围脑干肿瘤切除术后带管患者对气管导管的耐受性。方法选取围脑干肿瘤患者40例，常规全麻下行围脑干肿瘤切除手术。术毕前30min随机分为两组：D组右美托咪定0．3-0．5μg·kg^-1·h^-1静脉泵注至术后24h，M组咪达唑仑0．05mg·kg^-1·h^-1静脉泵注至术后24h。观察患者对气管导管的耐受性以及血流动力学指标和呼吸指标的变化。结果D组20例患者均对气管导管的耐受性良好，且血流动力学及呼吸指标稳定。M组患者中5例对气管导管不能耐受，5例耐受性欠佳，10例耐受良好；M组患者有轻度呼吸抑制，血流动力学指标波动明显。结论有美托咪定用于术后带管患者，气管导管耐受性良好、无呼吸抑制、血流动力学稳定，是对术后带管患者理想的解决方案。Objective To investigate the clinical application of dexmedetomidine on the patients with endotra- cheal tube after brain surgery.Methods 40 patients undergoing elective surgery for excision of brain stem tumor under general anesthesia were enrolled and randomly divided into 2 groups, dexmedetomidine group （group D, n=20） and midazolam group （group M, n=20）. Dexmedetomidine 0.3-0.5 μg·kg^-1·h^-1was administered for 24 hours to the patients in group D, while midazolam 0.05 rag·kg^-1·h^-1 was administered for 24 hours to the patients in group M. The tolerance to the endotracheal tube, the parameters of hemodynamics and respiration were recorded. Results All patients in group D tolerated to the endotracheal tube very well. The hemodynamic parameters and the parameters of respiration in group D were stable. In group M, 5 patients could not tolerate to the endotracheal tube, 5 patients tolerated to the endotracheal tube not very well and 10 ones did well. Mild respiratory depression was recorded in group M, and the parameters of hemodynamics in group M fluctuated obviously.Conclusion The patients with endotracheal tube after surgery administered with dexmedetomidine tolerate to the endotracheal tube very well, the hemodynamic and respiratory parameters are stable.

关 键 词：气管导管耐受性 右美托咪定 咪达唑仑 

分 类 号：R614[医药卫生—麻醉学]