肥胖对子宫内膜的影响  

The Influence of Obesity on endometrium

作　　者：李晓红[1] 李瑾[1] 易红[1] 

机构地区：[1]深圳市宝安区妇幼保健院生殖健康科,广东深圳518000

出　　处：《赣南医学院学报》2012年第2期203-205,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨肥胖对子宫内膜的影响及肥胖患者内分泌改变对子宫内膜的影响。方法:将异常子宫出血的患者分为肥胖组与非肥胖,对比分析两组患者子宫内膜病理检查的结果及肥胖患者内分泌改变对子宫内膜的影响。结果:肥胖组非正常子宫内膜(包括子宫内膜增生及癌变)高于非肥胖组,差异有统计学意义(P﹤0.01)。肥胖组雌激素水平高于对照组,差异有统计学意义(P﹤0.05)。促性腺激素(促卵泡素FSH、促黄体生成素LH)水平无显著差异(P﹥0.05)。肥胖组HOMA-IR明显高于非肥胖组,差异有统计学意义(P﹤0.01)。结论:肥胖与子宫内膜增生和子宫内膜癌有明显的相关性,肥胖患者的高雌激素、高胰岛素血症和胰岛素抵抗是影响子宫内膜增生、子宫内膜癌的重要因素,在治疗过程中应注意及早发现并给予治疗。Objective： To investigate the influence of obesity and the endocrine changes of the patients with obesity on en-dometrium. Method： The patients with abnormal uterine bleeding were divided into two groups of obesity and non - obesity, comparing the resuhs of endometrial pathologic examination between th two groups and studying the influence of the en- docrine changes of the patients with obesity on endometrium. Results ：The rate of abnormal endometrium（ including endo- metrial hyperplasia and carcinoma） in the group of obesity is higher than that of the group of non-obesity, with statistical significance （P 〈 0.01 ）. The estrogen level of the group of obesity is higher than that of the group of non-obesity, with statistical significance （ P 〈 0.05 ）. The HOMA-IR of the group of obesity is much higher than that of the group of non- obesity, with statistical significance （P 〈 0.01 ）. Conclusion：Endometrial hyperplasia and endometrial carcinoma have obvious correlation with obesity. Hyperestrinemia, hyperinsulinemia and insulin resistance are the important causes of Endometrial hyperplasia, endometrial carcinoma. Earlier diagnosis and treatment are vital.

关 键 词：肥胖 胰岛素抵抗 高胰岛素血症 子宫内膜增生 子宫内膜癌 

分 类 号：R711.74[医药卫生—妇产科学]