慢性肝炎肝硬化及原发性肝癌患者血清肿瘤坏死因子-α及白细胞介素-10水平变化  

The changes of level of tumor necrosis factor-α and interleukin-10 of chronic hepatitis and liver cirrhosis and primary liver cancer

作　　者：郭力红[1] 张岁[1] 刘英辉[2] 刘静[1] 佟立新[1] 

机构地区：[1]河北医科大学第一医院肝病中心,河北石家庄050031 [2]河北医科大学第三医院感染科

出　　处：《现代预防医学》2012年第11期2876-2878,共3页Modern Preventive Medicine

摘　　要：目的观察慢性肝炎、肝硬化以及原发性肝癌血清肿瘤坏死因子受体、白细胞介素-10水平的变化。方法回顾性分析2010年1月-2011年12月某院收治的63例肝炎肝硬化患者和57例原发性肝癌患者的血清检验资料,分析肿瘤坏死因子-α(TNF-α)及白细胞介素-10(IL-10)水平变化。结果①慢性肝炎肝硬化Child C级患者TNF-α水平(1.32±0.12)高于ChildB级(1.86±0.19)、A级(2.35±0.32),比较差异有统计学意义(P﹤0.05);慢性肝炎肝硬化Child A级患者IL-10水平(0.037±0.010)高于Child B级(0.024±0.009)、C级(0.013±0.004),比较差异有统计学意义(P﹤0.05)。②原发性肝癌组患者血清TNF-α水平(3.56±0.15)高于慢性肝炎肝硬化组患者(2.32±0.22)、对照组患者(0.63±0.10),比较差异有统计学意义(P﹤0.05);原发性肝癌患者组血清IL-10水平(0.014±0.009)低于慢性肝炎肝硬化组患者(0.027±0.012)、对照组患者(0.046±0.004),比较差异有统计学意义(P﹤0.05)。结论TNF-α和IL-10均参与慢性肝炎肝硬化和原发性肝癌的病理过程,TNF-α水平变化趋势与疾病严重程度一致,IL-10水平变化趋势与疾病严重程度相反。OBJECTIVE To observe the changes of level of tumor necrosis factor-α and interleukin-10 of chronic hepatitis and liver cirrhosis and primary liver cancer.METHODS From January 2010 to December 2011,the changes of level of tumor necrosis factor-α（TNF-α）and interleukin-10（IL-10）of 63 patients with chronic hepatitis and liver cirrhosis and 57 patients with primary liver cancer were retrospectively analyzed.RESULTS ① The level of TNF-α of chronic hepatitis patients with liver cirrhosis Child grade C（1.32±0.12）,was higher than Child grade B（1.86±0.19）or Child grade A（2.35±0.32,the difference was statistically significant（P﹤0.05）;the level of IL-10 of chronic hepatitis patients with liver cirrhosis Child grade A（0.037±0.010）,was higher than Child grade B（0.024±0.009）or Child grade C（0.013±0.004）,the difference was statistically significant（P﹤0.05）.② The level of TNF-α of primary liver cancer groups（3.56±0.15）,was higher than the chronic hepatitis and liver cirrhosis group（2.32±0.22）,control group（0.63±0.10）,the difference was statistically significant（P﹤0.05）;the level of IL-10 of primary liver cancer groups（0.014±0.009）,was higher than the chronic hepatitis and liver cirrhosis group（0.027±0.012）,control group（0.046±0.004）,the difference was statistically significant（P﹤0.05）.CONCLUSION TNF-α and IL-10 are involved in pathological process of chronic hepatitis and liver cirrhosis and primary liver cancer,the level change trend of TNF-α and disease severity is consistent,the level change trend of IL-10 and disease severity is opposite.

关 键 词：慢性肝炎肝硬化 原发性肝癌 肿瘤坏死因子-Α 白细胞介素-10 

分 类 号：R657.31[医药卫生—外科学] R735.7[医药卫生—临床医学]