磷霉素钠结合中药治疗慢性肺心病急性加重期的疗效观察  

Clinical observation on fosfomycin sodium combined with Chinese traditional medicine treatment in acute exacerbation of chronic cor pulmonale

作　　者：张振国 邱作成[2,3] 李志钢[2,3] 乐德行[2,3] 

机构地区：[1]乌鲁木齐市公安消防支队后勤处卫生队,乌鲁木齐830002 [2]新疆维吾尔自治区中医院 [3]新疆医科大学附属中医院

出　　处：《现代预防医学》2012年第11期2899-2900,2902,共3页Modern Preventive Medicine

摘　　要：目的观察磷霉素钠注射液联合自拟肺心Ⅰ号方治疗慢性肺源性心脏病(CPHD)急性加重期的疗效。方法全部122例患者随机分为2组,治疗组82例,对照组40例,在常规应用吸氧、止咳、解痉平喘、强心、利尿、纠正电解质和酸碱失衡基础上,对照组给予头孢哌酮钠舒巴坦钠注射液及血塞通注射液静脉滴注,治疗组给予磷霉素钠注射液静脉滴注,并口服肺心Ⅰ号方。于治疗后检查动脉血气、血浆D—二聚体、血红蛋白和血液流变学等。结果治疗组总有效率93.90%,对照组总有效率62.50%,两组相比,差异有统计学意义(P﹤0.01),治疗组治疗后各项实验室指标改善均较对照组明显(P﹤0.05或P﹤0.01)。结论磷霉素钠联合中药治疗CPHD急性加重期疗效肯定,并发症少,复发率及死亡率低,且副作用小。OBJECTIVE To observe the curative effects of fosfomycin sodium jointed with Pulmonary heart Ⅰprescription in treatment acute exacerbation of chronic cor pulmonale（CPHD）.METHODS All 122 cases were randomly divided into two groups,the treatment group of 82 cases,the control group of 40 cases.On the basis of routine use of oxygen,relieving a cough,relieving asthma and spasm,making heart strong,diuresis and correcting electrolyte and acid-base imbalances,the control group was given cefoperazone sodium sulbactam plug Xuesaitong injection by intravenous drip,the treatment group was given fosfomycin sodium injection by intravenous drip,and Pulmonary heart Ⅰprescription.Checked arterial blood gas,plasma D-dimer,hemarheology,etc.after treatment.RESULTS Total effectiveness rate was 93.90% in the treatment group,which in the control group 62.50%（P﹤0.01）.Compared to two groups,laboratory index improved significantly in the treatment group than in the control group after the treatment（P﹤0.05 or P﹤0.01）.CONCLUSION Fosfomycin sodium jointed Chinese medicine treatment in acute exacerbation CPHD assures curative effects,less complications,low recurrence rate and mortality rate,and less side effects.

关 键 词：慢性肺心病急性加重期 磷霉素钠 肺心Ⅰ号方 菌毒并治 

分 类 号：R541.5[医药卫生—心血管疾病]