对比分析无聚合物紫杉醇涂层支架与可降解聚合物雷帕霉素涂层支架治疗冠心病的效果  

Comparison of polymer-free paclitaxel-eluting stent and biodegradable polymer-based rapamycin-eluting stent in the treatment of coronary heart disease

作　　者：王小凤[1] 

机构地区：[1]荆楚理工学院医学院,湖北荆门448000

出　　处：《现代预防医学》2012年第11期2918-2919,2926,共3页Modern Preventive Medicine

摘　　要：目的对比分析无聚合物紫杉醇涂层支架(垠艺)与可降解聚合物雷帕霉素涂层支架(Excel)治疗冠心病的疗效与安全性。方法选择某院收治的125例冠心病患者,随机分为垠艺组和Excel组,接受PCI治疗。临床随访1年,观察两组支架内有无血栓形成、主要心脏不良事件(MACE)、死亡原因及再次入院情况。结果两组患者均没有发生晚期肯定性支架血栓。共有6例患者死亡,垠艺组2例,Excel组4例。垠艺组的主要心脏不良事件和再次入院率与Excel组的数据近似,差异均没有统计学意义(P﹥0.05)。结论无聚合物紫杉醇涂层支架与可降解聚合物雷帕霉素涂层支架在治疗冠心病及预防心血管疾病作用相当,均有良好的效果。OBJECTIVE To compare the efficiency and safety of polymer-free paclitaxel-eluting stent（YINYI）and biodegradable polymer-based rapamycin-eluting stent（Excel）in the treatment of coronary heart disease.METHODS 125 patients with coronary heart disease were randomly divided into YINYI group and Excel group before PCI treatments.Clinical follow-up was performed for 1 year.The in-stent thrombosis,major adverse cardiac events（MACE）,deaths and re-admission were assessed.RESULTS Both the two groups of patients had no late stent thrombosis.There were 6 patients died in this study with 2 cases in YINYI group and 4 cases in Excel group.MACE and re-admission rates in YINYI group were similar with those in Excel group.The differences was not statistically significant（P﹥0.05）.CONCLUSION The polymer-free paclitaxel-eluting stent and the biodegradable polymer-based rapamycin-eluting stent have the same efficiency in the treatment of coronary heart disease.

关 键 词：冠心病 聚合物 血栓 药物涂层支架 

分 类 号：R541.4[医药卫生—心血管疾病]