山西省六县（市）主要出生缺陷影响因素分析  

Analysis of influencing factors leading to major birth defects in six counties of Shanxi province

作　　者：张红[1] 王芳芳[2] 郭兴萍 安焕晓 王钰[1] 白云[5] 

机构地区：[1]山西省眼科医院办公室,太原030012 [2]山西省眼科医院人事科 [3]山西省人口计划生育科研所生殖科 [4]山西省人大委员会办公厅 [5]山西省妇幼保健院妇女保健科

出　　处：《中华全科医师杂志》2012年第5期369-371,共3页Chinese Journal of General Practitioners

摘　　要：为了解山西省主要出生缺陷发生率及其影响因素，于2009年11至12月对山西省6个县（市）0～3岁婴幼儿及母亲进行横断面和回顾性调查。六县（市）出生缺陷发生率为134．27／万（493／36716）；前5位出生缺陷排序为先天性心脏病、神经管畸形、唇腭裂、多指（趾）并指（趾）、智力低下，每种出生缺陷的危险因素和保护因素各有不同，其中亲属缺陷儿史、既往缺陷儿史、孕产次多、孕期服解热镇痛药为其共同危险因素。开展孕前指导、危险因素筛查和评估，孕期预防疾病是预防出生缺陷的关键。To explore the influencing factors of major birth defects. The children of 0 -3 years and their mother from six different districts were surveyed from November 2009 to December 2009. The incidence rate was 134. 27/10 000（493/36 716）in 6 counties. And the first five birth defects were as follows： congenital heart disease, neural tube defects, cheilopalatognathus, polydactylia and hypophrenia. The risks and protective factors of the first 5 birth defects were different. Anamnesis of birth defects and defective children from relatives, multiple pregnancy ＆ birth and intake of antipyretic analgesics during pregnancy were the common risk factor for the first 5 birth defects. The key points for the prevention of birth defects are to reinforce the pre-pregnancy guidance, the screening and evaluation of risk factors and disease prevention during pregnancy.

关 键 词：出生缺陷 影响因素 

分 类 号：R174[医药卫生—妇幼卫生保健]