多囊卵巢综合征患者血清游离脂肪酸水平测定及其相关因素分析  

Concentration of serum free fatty acids and its correlation analyses in patients with polycystic ovarian syndrome

作　　者：宋颖[1] 李启富[1] 田波[1] 钟立[1] 杨淑敏[1] 夏伟[1] 毕小云[2] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016 [2]重庆医科大学附属第一医院检验科,400016

出　　处：《重庆医学》2012年第16期1585-1588,共4页Chongqing medicine

摘　　要：目的分析多囊卵巢综合征(PCOS)患者血清游离脂肪酸(FFAs)水平的变化,并探讨其相关因素。方法纳入133例PCOS患者及116例年龄匹配的健康女性,测量身高、体质量、腰围;行75g无水葡萄糖耐量试验,并测空腹血清血脂、空腹胰岛素(FINS)、血清FFAs、总睾酮,计算胰岛素抵抗指数(HOMA-IR);对101例PCOS患者及20例正常人行高胰岛素-正葡萄糖钳夹术。结果 PCOS患者血清FFAs水平明显高于对照组(P<0.01);亚组分析显示,与两个体质量匹配的对照组相比,PCOS患者的FFAs水平也明显增高(P<0.01)。相关分析显示,FFAs水平与体质量指数(BMI)、腰围、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)、总睾酮(r分别为0.20、0.18、0.19、0.18、0.18,P<0.05)呈正相关;与高密度脂蛋白胆固醇(HDL-c)、稳态期120～180min葡萄糖代谢率(M120-180)(r分别为-0.17、-0.22,P<0.05)呈负相关。结论与年龄匹配的健康妇女相比,PCOS患者血清FFAs水平显著升高,且与BMI、腰围、TC、LDL-c、总睾酮水平呈正相关,与HDL-c、M120-180呈负相关。Objective To measure the concentration of free fatty acids（FFAs）and to analyze its associations with correlative factors in the patients with polycystic ovarian syndrome（PCOS）. Methods 133 PCOS women and 116 healthy,age-matched controls were recruited. Physical examination and laboratory analysis were performed. All subjects underwent a standard 75-g oral glucose tolerance test. 101 PCOS women and 20 controls underwent hyperinsulinemic euglycemic clamp to assess their insulin sensitivity. IR was also estimated by homeostasis model assessment of insulin resistance（HOMA-IR）. Results The levels of serum FFAs in P- COS women were significantly higher as compared with controls （P〈0.01）. Subgroup analysis showed that the levels of serum FFAs in two PCOS subgroups were significantly higher as compared with the two weight-matched control subgroups（P〈0.01）. Correlation analyses showed that in all subjects,FFAs positively correlated with BMI, waist circumference, total cholesterol（TC）, LDL-c and total testosterone（r=0.20,r=0.18,r=0.19,r=0. 18,r=0. 18,P〈0.05） and negatively correlated with HDL-c and M120-180 value（r= -0.17,r=-0.22,P〈0.05）. Conclusion Comparing with age-matched healthy women,the levels of serum FFAs in PCOS women are elevated evidently and positively correlated with BMI,waist circumference, TC, LDL-c and total testos- terone, negatively correlated with HDL-c and M120-180 value.

关 键 词：多囊卵巢综合征 游离脂肪酸 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]