In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy  

作　　者：WANG YongPing HE YaoHua ZHU ZhaoJin JIANG Yao ZHANG Jian NIU JiaLin MAO Lin YUAN GuangYin 

机构地区：[1]Department of Orthopaedics,Sixth People's Hospital of Shanghai Jiao Tong University,Shanghai 200233,China [2]National Engineering Research Center of Light Alloys Net Forming,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Chinese Science Bulletin》2012年第17期2163-2170,共8页

基　　金：supported by the National Natural Science Foundation of China (81071452 and 30772182)

摘　　要：In this study,in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr(NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial.Its corrosion properties were evaluated by static immersion test,electrochemical corrosion test,scanning electron microscopy(SEM),and energy dispersive spectroscopic(EDS) analysis,and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests.Pure magnesium was used as control.The results of static immersion test and electrochemical corrosion test in simulated body fluid(SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance.The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%,which was lower than the safe value of 5%.The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-E1 cell viability.Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro.Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.In this study, in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr （NZK） alloy were investigated to determine its suitability as a degradable medical biomaterial. Its corrosion properties were evaluated by static immersion test, electrochemical corrosion test, scanning electron microscopy （SEM）, and energy dispersive spectroscopic （EDS） analysis, and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests. Pure magnesium was used as control. The results of static immersion test and electrochemical corrosion test in simulated body fluid （SBF） demonstrated that the addition of alloying elements could improve the corrosion resistance. The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%, which was lower than the safe value of 5%. The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-EI cell viability. Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro. Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degrada- ble medical biomaterial for orthopedic applications.

关 键 词：生物相容性 体外降解 锆合金 纯镁 电化学腐蚀试验 医用生物材料 扫描电子显微镜 溶血试验 

分 类 号：TG146.22[一般工业技术—材料科学与工程]