金属硫蛋白聚合中阳离子作用机制的研究  

Theoretic Studies on the Mechanism of Cations in MetallothioneinsPolymerization

作　　者：侯廷军[1] 安钰[2] 廖宁[1] 茹炳根[2] 徐筱杰[1] 

机构地区：[1]北京大学化学与分子工程学院 [2]北京大学生命科学学院,北京100871

出　　处：《物理化学学报》2000年第4期356-361,共6页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金重大项目资助!(299925902)

摘　　要：It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated.From the analyses of electrostatic potential, two binding sites of cations can be determined:The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole.The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated.From the analyses of electrostatic potential, two binding sites of cations can be determined:The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole.The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.

关 键 词：金属硫蛋白 静电势 负电势孔值 阳离子 二聚体 

分 类 号：O631[理学—高分子化学]