高效液相色谱法拆分外消旋药物联苯双酯及其衍生物  

Enantiomeric Separation of Biphenyl Dicarboxylate and Its Derivatives by High Performance Liquid Chromatography

作　　者：刘月启[1] 于兆文[1] 蒋生祥[1] 李永民[1] 陈立仁[1] 常俊标[2] 郭瑞云[2] 

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000 [2]河南省化学研究所,郑州450002

出　　处：《分析化学》2000年第3期307-310,共4页Chinese Journal of Analytical Chemistry

基　　金：中国科学院重点基金

摘　　要：合成并制备了纤维素-三（3，5-二甲基苯基氨基甲酸酯）手性固定相，利用高效液相色谱法首次直接拆分了5种外消旋联苯类药物，考察了流动相组成，样品结构对保留和拆分的影响。Cellulose tris-(3, 5 - dimethylphenylcdrite) was synthesized and used as a chiral stationary phase after it was adsorpted on silica gel. Five racemic biphenyl antiliepatitis drugs have been for the first time directly resolved on the stationary phase by normal-phase high performance liquid chrmatography.The effect of 2-propanol concentration in mobile phase and the smicture of the analytes on the retention and resolution were investigated.

关 键 词：高效液相色谱法 联苯双酯 保肝药物 手性拆分 

分 类 号：O657.7[理学—分析化学]