核因子κB与糖尿病肾病关系的研究进展  

Research Progress of the Correlation between Nuclear Factor-κB and Diabetic Nephropathy

作　　者：赵建芹[1] 姜兆顺[1] 穆红[1] 韩晨东[1] 

机构地区：[1]济南军区总医院内分泌科,济南250031

出　　处：《医学综述》2012年第9期1388-1391,共4页Medical Recapitulate

摘　　要：核因子κB(NF-κB)是一种广泛存在并具有广泛生物学活性的核转录因子,其调控的靶基因包括细胞因子、趋化因子、转录因子、氧化应激相关酶及急性期蛋白等,进而参与调控炎症和免疫反应、细胞生长发育、细胞凋亡及应激反应等多种生物过程。研究发现在糖尿病肾病(DN)的局部肾组织中存在过度激活的NF-κB,其过度激活与肾小球系膜细胞增生和分泌炎性因子密切相关。因此,深入研究NF-κB与DN的关系,有助于DN的临床防治。Nuclear factor-κB（NF-κB）is a transcription factor widely distributed in most cell types with extensive biologic activity,which regulates the expression of numerous genes such as cytokine,chemotactic factor,transcriptionfactor,oxidative stress related enzymes,and acute-phase proteins etc.,accordingly participating in many bioprocesses such as inflammation responses,immunoreaction,apoptosis and stress reaction etc..It has been found that excessive activation of NF-κB which exists in local nephridial tissue of diabetic nephropathy（DN）has a closely relationship with the proliferation of mesangial cell and the secretion of inflammatory factors.Therefore,deeper study of the relationship between NF-κB and DN contributes to the clinical prevention and therapy.

关 键 词：核因子ΚB 糖尿病 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]