2型糖尿病患者大血管病变危险因素与颈动脉粥样硬化斑块稳定性的相关分析  

Research on the Risk Factors of Patients with Type 2 Diabetes Macrovascular Disease and the Stability of Carotid Atherosclerotic Plaques

作　　者：付金凤[1] 徐洁[2] 李阳[2] 

机构地区：[1]湖北中医药大学,武汉430065 [2]武汉市第一医院内分泌科,武汉430000

出　　处：《医学综述》2012年第9期1424-1426,共3页Medical Recapitulate

摘　　要：目的探讨2型糖尿病大血管病变危险因素与颈动脉粥样硬化斑块稳定性的相关性。方法选取2010年12月至2011年9月武汉市第一医院内分泌科住院2型糖尿病患者132例,根据颈动脉彩超结果将其分为有不稳定斑块组,稳定斑块组及无斑块组,评估入组糖化血红蛋白(HbA1c)、血尿酸(SUA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(Fib)、空腹血糖(FBG)等糖尿病大血管病变危险因素。结果不稳定斑块组及稳定性斑块组的血清Fib、SUA、LDL-C、hs-CRP、HbA1c水平较对照组具有显著性差异(P<0.01)。不稳定斑块组的血清Fib、SUA、hs-CRP、HbA1c水平较稳定性斑块组有显著性差异(P<0.01)。结论 Fib、SUA、hs-CRP、HbA1c等2型糖尿病大血管病变危险因素与颈动脉粥样硬化不稳定性斑块的形成可能具有相关性。Objective To explore the relevance of the risk factors for Type 2 Diabetes Mellitus（T2DM）macrovascular disease and the stability of carotid atherosclerotic plaques.Methods A total of 132 patients with T2DM in Wuhan NO.1 hospital from December 2010 to September 2011 were included.132 patients with T2DM were divided into unstable plaque group,stable plaque group and non-plaque group by Color Doppler Ultrasound,the risk factors of macrovascular disease such as glycosylated hemoglobin A1c（HbA1c）,serum uric acid（SUA）,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,high sensitivity C-reactive protein（hs-CRP）,fibrinogen,fasting blood glucose and so on were assessed.Results There were significant differences in blood Fib,SUA,LDL-C,hs-CRP,HbA1c levels in the unstable plaque group and stable plaque group contrast with non-plaque groups（P〈0.01）.There were significant differences in blood Fib,SUA,hs-CRP、HbA1c levels in the unstable plaque group contrast with stable plaque group（P〈0.01）.Conclusion Such risk factors for T2DM macrovascular disease as Fib,SUA,hs-CRP,HbA1c may have a certain relevance with stability of carotid atherosclerotic plaques.

关 键 词：糖尿病 大血管病变 颈动脉粥样硬化斑块 

分 类 号：R587.2[医药卫生—内分泌]