理肺散化学成分研究  

Chemical constituents from whole herb of Hedyotis scandens

作　　者：邓芳叶[1,2] 王国才[1,2] 王春华[1,2] 叶文才[1,2] 

机构地区：[1]暨南大学药学院中药及天然药物研究所,广东广州510632 [2]暨南大学中药药效物质基础及创新药物研究广东省高校重点实验室,广东广州510632

出　　处：《中草药》2012年第5期861-865,共5页Chinese Traditional and Herbal Drugs

摘　　要：目的研究理肺散原植物攀援耳草Hedyotis scandens的化学成分。方法采用硅胶、ODS、Sephadex LH-20及RP-HPLC等色谱技术对理肺散的化学成分进行分离纯化,根据理化性质及波谱数据鉴定化合物结构。结果从理肺散的醋酸乙酯部位分离得到了13个化合物,分别鉴定为齐墩果酸(1)、2α,3α,24-三羟基-12-烯-28-齐墩果酸(2)、2α,3β,24-三羟基-12-烯-28-齐墩果酸(3)、2α,3β-二羟基-12-烯-28-乌苏酸(4)、2α,3β,19α-三羟基-12-烯-28-乌苏酸(5)、白桦酸(6)、山柰酚-3-O-β-D-葡萄糖苷(7)、槲皮素(8)、芹菜素(9)、芹菜素-7-O-β-D-葡萄糖苷(10)、木犀草素(11)、木犀草素-7-O-β-D-葡萄糖苷(12)和胡萝卜苷(13)。结论化合物1～13均为首次从该植物中分离得到。Objective To investigate the chemical constituents in the whole herb of Hedyotis scandens.Methods The chemical constituents were isolated and identified by column chromatography on silica gel,ODS,Sephadex LH-20,as well as RP-HPLC.Their structures were elucidated on the basis of physicochemical properties and spectral analyses.Results Thirteen compounds were isolated from H.scandens and structures were identified as oleanolic acid（1）,2α,3α,24-trihydroxy-olea-12-en-28-oic acid（2）,2α,3β,24-trihydroxy-olea-12-en-28-oic acid（3）,2α,3β-dihydroxy-urs-12-en-28-oic acid（4）,2α,3β,19α-trihydroxy-urs-12-en-28-oic acid（5）,betulinic acid（6）,kaempferol-3-O-β-D-glucoside（7）,quercetin（8）,apigenin（9）,apigenin-7-O-β-D-glucoside（10）,luteolin（11）,luteolin-7-O-β-D-glucoside（12）,and daucosterol（13）,respectively.Conclusion Compounds 1—13 are isolated from H.scandens for the first time.

关 键 词：理肺散 攀援耳草 茜草科 2α 3α 24-三羟基-12-烯-28-齐墩果酸 2α 3β-二羟基-12-烯-28-乌苏酸 白桦酸 

分 类 号：R284.1[医药卫生—中药学]