PTC法合成5-芳基-2-呋喃甲酸四乙酰葡萄糖酯  

Synthesis of Tetraacetyl Glucosyl Esters of 5 - Aryl - 2 - Furoic Acidsby Phase Transfer Catalysis

作　　者：刘明国[1] 童开发[1] 罗光富[1] 廖全斌[1] 付莎莉[2] 

机构地区：[1]湖北三峡学院化学系,宜昌443000 [2]武汉大学化学系,武汉430072

出　　处：《有机化学》2000年第2期198-201,共4页Chinese Journal of Organic Chemistry

摘　　要：采用ＰＴＣ法合成了４个５－芳基－２－呋喃甲酸四乙酰葡萄糖酯，通过元素分析、ＩＲ、＾１ＨＮＭＲ及ＭＳ确证了糖酯的结构，并试验了所合成的糖酯的杀菌活性。通过对糖酯化合物的＾１ＨＮＭＲ谱图中糖环碳１位质子的化学位移及偶合常数分析，结合ＩＲ谱图中糖环Ｃ１－Ｈ的弯曲振动吸收，确证它们均为β型异构体。Four new tetraacetyl glucosyl esters of 5 - aryl - 2 - furoic acids were synthesized under phase transfer conditions, characterized by elemental analysis, IR, 1H NMR and MS spectroscopy, and tested for the antibacterial activity . The 1H NMR spectra showed that they were B - anomer. The PTC method has the advantages of mild reaction conditions , easy seperation of products and high stereosselectivity.

关 键 词：PTC法 合成 四乙酰葡萄糖酯 β型异构体 

分 类 号：O629[理学—有机化学]