代谢综合征患者血清磷脂脂肪酸构成及其与胰岛素抵抗的关系研究  

Serum phospholipid fatty acid and insulin resistance in patients with metabolic syndrome

作　　者：肖新才[1] 刘健 罗晓林[3] 罗不凡[1] 苏宜香[3] 

机构地区：[1]广州市疾病预防控制中心,广东广州510440 [2]广州市番禺疗养院,广东广州511490 [3]中山大学公共卫生学院,广东广州510080

出　　处：《中华疾病控制杂志》2012年第5期388-391,共4页Chinese Journal of Disease Control & Prevention

基　　金：广州市医学科研基金(2007-yb-126)

摘　　要：目的研究代谢综合征患者血清磷脂脂肪酸构成及其与胰岛素抵抗的关系。方法采集87例代谢综合征患者和102名健康者血样,采用色谱/质谱联合分析其血清磷脂脂肪酸构成,用胰岛素抵抗指数(homeostasismodel assessment-insulin resistance,HOMA-IR)评价调查对象胰岛素抵抗。结果代谢综合征组饱和脂肪酸(saturat-ed fatty acid,SFA)、n-6/n-3多不饱和脂肪酸(n-6/n-3 polyunsaturated fatty acid,n-6/n-3 PUFA)比值较健康对照组升高(均有P<0.001),PUFA/SFA比值较健康对照组降低(P<0.001)。相关性分析显示HOMA-IR与n-6/n-3 PU-FA呈正相关,与n-3 PUFA呈负相关。结论代谢综合征患者存在血清磷脂脂肪酸构成改变现象,SFA增高而PU-FA降低,而且n-3 PUFA与胰岛素抵抗呈负相关。提示代谢综合征患者应减少SFA摄入,注意补充n-3 PUFA。Objective To investigate the relationship between the serum phospholipid fatty acid and insulin resistance in patients with metabolic syndrome（MS）.Methods Serum phospholipid fatty acid profile was analyzed with gas chromatography-mass spectrometer（GC/MS） in 87 MS patients and 102 healthy subjects.Insulin resistance was assessed by homeostasis model assessment-insulin resistance（HOMA-IR）.Results The percentage of saturated fatty acid（SFA）and the ratio of n-6 polyunsaturated fatty acid（PUFA） to n-3 PUFA were higher in MS patients than those in healthy control group（all P〈0.001）.But the ratio of PUFA to SFA were lower in MS group than those in control group（P〈0.001）.HOMA-IR was positively correlated with n-6/n-3 PUFA,but negatively correlated with n-3 PUFA.Conclusions Serum phospholipid fatty acid was changed in MS patients,SFA was significantly higher than those of healthy control group,but PUFA in MS group was significantly lower than those of healthy control group.n-3 PUFA was negatively correlated with insulin resistance in MS.

关 键 词：代谢疾病 脂肪酸类 胰岛素抗药性 

分 类 号：R589[医药卫生—内分泌] R181.3[医药卫生—内科学]