慢性阻塞性肺疾病与多药耐药相关蛋白1的相关性研究进展  

Advance on the relationship between chronic obstructive pulmonary disease and multidrug resistance-associated protein 1

作　　者：张弦[1] 汪电雷[1] 陶秀华[1] 曹银[1] 

机构地区：[1]安徽中医学院省现代中药重点实验室,安徽合肥230038

出　　处：《安徽医药》2012年第5期573-575,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(No 81001592);教育部科学技术重点项目(No 210101);安徽高校省级自然科学研究重点项目(NoKJ2010A210)

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是肺部常见疾病,与肺部对有害气体或有害颗粒的异常炎症反应有关,其中炎症反应和氧化应激等扮演着重要的角色。多药耐药相关蛋白(multidrug resistance-associated protein 1,MRP1)是一种依赖于ATP介导底物跨膜转运蛋白。近年来研究表明,MRP1在肺部广泛表达,且有着特定的生物学功能,如介导外源性有毒物质的外排,内源性物质炎症介质LTC4及GSH等的跨膜转运,其生物学功能的改变在COPD的发生和发展过程中发挥着重要作用。通过了解MRP1在肺部疾病的功能,有利于进一步理解MRP1和COPD的关系,从而更好地指导COPD的治疗。Chronic obstructive pulmonary disease（COPD） is a common pulmonary disease,which is related to the abnormal inflammatory response of noxious gases and particle.Inflammatory response and oxidative stress play an important role in COPD.Multidrug resistance-associated protein 1 transport substrates across cell membranes in an ATP-dependent manner.In recent years,the research shows that MRP1 is highly expressed in the lung.MRP1 has a special biological function,mediates the efflux of toxic substances and transports the endogenic mediators of inflammation LTC4 and GSH across cell membranes.The change of biological function plays an important role in the lung and correlated disease＇ occurrence and development.Investigating the function of MRP1 in the lung and correlated disease（e.g.COPD） is beneficial to make a further understanding of the relation between MRP1 and COPD,and to guide the better treatment of COPD.

关 键 词：慢性阻塞性肺疾病 多药耐药相关蛋白1 白三烯C4 谷胱甘肽 氧化应激 

分 类 号：R563.9[医药卫生—呼吸系统]