HBeAg阴性慢性乙型肝炎患者血清HBV DNA含量与ALT的关系  

Correlation between serum HBV DNA and alanine aminotransferase levels in patients with HBeAg-negative chronic hepatitis B

作　　者：陈萍[1] 李旭[1] 苏菲[1] 李娜[1] 郜玉峰[2] 

机构地区：[1]安徽医科大学第一附属医院感染病科,安徽合肥230022 [2]安徽医科大学第二附属医院肝病科,安徽合肥230601

出　　处：《安徽医药》2012年第5期618-620,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(No 81072342)

摘　　要：目的探讨HBeAg阴性慢性乙型肝炎患者血清HBV DNA含量与ALT的关系。方法回顾性分析269例乙型肝炎患者的临床资料和实验室检测数据,HBeAg阴性组148例和阳性组121例,对比分析两组患者HBV DNA含量及ALT水平的关系。结果 148例HBeAg阴性乙型肝炎患者中血清HBV DNA阳性者107例(72.3%),其均值为(5.4±1.3)log10copies.ml-1,血清ALT水平为49(129.0)IU.L-1(中位数,四分位数间距),肝硬化比例为51.4%(55/107)。121例HBeAg阳性乙型肝炎患者中血清HBV DNA阳性118例(97.5%),其均值为(6.8±1.2)log10copies.ml-1,ALT水平为105(139.5)IU.L-1(中位数,四分位数间距),肝硬化比例为13.6%(16/118)。HBV DNA阳性率及含量和ALT水平HBeAg阳性组高于HBeAg阴性组(P<0.01)。ALT水平在HBeAg阴性伴HBV DNA阳性组与HBeAg阳性伴HBV DNA阳性组比较无统计学意义(Z=-1.43,P=0.15>0.05)。肝硬化在HBeAg阴性伴HBV DNA阳性组所占比例最高。HBeAg阴性组较HBeAg阳性组患者的年龄较大(t=7.046,P<0.01)。结论 HBeAg阴性慢性乙型肝炎患者年龄偏大,肝硬化比例偏高,尤其是HBV DNA阳性者,肝脏炎性损伤程度与HBeAg阳性患者相似。Objective To investigate the relationship between the level of serum HBV DNA and alanine aminotransferase（ALT） levels of patients with HBeAg-negative chronic hepatitis B.Methods All the 269 subjects（148 samples from HBeAg-negative group,121 samples from HBeAg-positive group） underwent the determination of HBV DNA and ALT by PCR and enzyme respectively,then its correlation was analyzed.Results HBV DNA positivity,cirrhosis,HBV DNA mean and ALT of 148 HBeAg-negative cases were 107（72.3%）,51.4%（55/107）,（5.4±1.3）log10copies·ml-1,and 49（129.0）（Median,Q）IU·L-1 respectively.HBV DNA positivity,cirrhosis,HBV DNA mean and ALT of 121 HBeAg-positive cases were 118（97.5%）,3.6%（16/118）,（6.8 ± 1.2）log10copies·ml-1,and 105（139.5）（Median,Q）IU·L-1,respectively.HBeAg-negative patients had a lower HBV DNA load and positivity,and they had more fibrotic changes in the liver than HBeAg-positive patients.The two groups did not differ in necroinflammatory activity,but the former had lower ALT value.Cirrhosis was more common in e-antigen-negative patients.Conclusion E-antigen-negative CHB patients are older and have a higher percentage of hepatic fibrosis.HBV DNA positive patients have similar necroinflammatory activity to HBeAg positive patients.

关 键 词：HBEAG阴性 乙型肝炎 HBV DNA 谷丙转氨酶 

分 类 号：R512.62[医药卫生—内科学]