前列腺素E_2对免疫细胞的调控影响  

Effects of prostaglandin E2 on the regulation of immune cells

作　　者：唐晓晏[1] 张艺 杜雄心 

机构地区：[1]川北医学院病理生理教研室,四川南充637000 [2]四川省南充市食品药品检验所,四川南充637000

出　　处：《吉林医学》2012年第13期2700-2701,共2页Jilin Medical Journal

摘　　要：目的:通过观察前列腺素E2(prostaglandin E2,PGE)对外周血T细胞增值的影响,分析其对免疫细胞(Th1和Th2细胞)的调节作用及影响。方法:应用抗CD3和抗CD28单克隆抗体(mAb)与健康成人外周血单个核细胞(MNC),RPMI 1640,10%胎牛血清(FBS),加PGE2为观察组,不加PGE2为对照组,观察组加入不同浓度的PGE2,与对照组对比观察。结果:在加入不同浓度PGE2的情况下,T细胞增值的抑制率有时显增加,与PGE2浓度呈正相关。结论:前列腺素E2在免疫细胞的发育分化及免疫应答过程中起着重要作用。Objective To observe the impact of prostaglandin E2 （prostaglandin E2, PGE） on peripheral blood T cell proliferation, and analyze its regulation and impact on their immune cells （ Th1 and Th2 cells）. Method The anti - CD3 and anti - CD28 monoclonal anti- body （mAb） and healthy adult peripheral blood mononuclear cells （ MNC）, RPMI 1640,10% fetal bovine serum （ FBS）, plus PGE2 was in the observation group,the control group was without PGE2. The observation group with different concentrations of PGE2 ,compared with the control group. Results In different concentrations of PGE2 ,T cell proliferation inhibition rates was significantly increased,with positive correlation with PGE2 concentration. Conclusion Prostaglandin E2 plays an important role in immune cell development and differentiation, and immune response.

关 键 词：前列腺素E2 免疫细胞 实验观察 

分 类 号：R96[医药卫生—药理学]