CpG寡核苷酸对鸡Toll样受体15表达量的影响  

Effect of CpG-ODN on the Expression of Chicken TLR15

作　　者：韩焱[1] 徐明玉[1] 孙楠[1] 

机构地区：[1]大连市疾病预防控制中心,辽宁大连116021

出　　处：《安徽农业科学》2012年第14期8106-8106,8177,共2页Journal of Anhui Agricultural Sciences

摘　　要：[目的]研究禽类TLR15受体在CpG-ODN诱导机体天然免疫反应中的作用。[方法]采用实时定量PCR等检测方法,检测CpG-ODN刺激后细胞因子和TLR15表达量的变化情况。[结果]CpG-ODN刺激鸡巨噬细胞后,可显著提高细胞因子和TLR15表达量。[结论]禽类TLR15受体可能参与了CpG-ODN刺激引起的机体天然免疫反应。[ Objective J To investigate the role of chicken TLR15 on CpG-ODN-induced innate immuneity. L Method J The expression of TLR15 and cytokines induced with CpG-ODN was determined by the real-time reverse-transcriptase PCR. [ Result ] The expression of cytokines and TLR15 was significantly improved in HD11 cells after CpG-ODN stimulation. [ Conclusion] Chicken TLR15 may be involved in CpG-ODN-stimu- lated innate immunity.

关 键 词：TOLL样受体 天然免疫 细胞因子 

分 类 号：S811.3[农业科学—畜牧学]