高同型半胱氨酸血症对2型糖尿病交感神经功能状态的影响  

Effects of Hyperhomocysteinemia on Sympathetic Nervous Function in Patients with Type 2 Diabetic Mellitus

作　　者：王素红[1] 张哲成[1] 刘娜[1] 朱炬[1] 张静[1] 

机构地区：[1]天津医科大学三中心临床学院神经内科,300170

出　　处：《天津医药》2012年第6期547-549,共3页Tianjin Medical Journal

摘　　要：目的:研究高同型半胱氨酸血症(Hhcy)对2型糖尿病(DM)交感神经功能状态的影响。方法:选取2型糖尿病Hhcy患者22例,并以22例2型糖尿病非Hhcy患者作为对照,采用丹麦Keypoint.net肌电图仪通过皮肤交感反射(SSR)检测技术,对2组患者进行四肢SSR测定,记录并比较2组患者SSR波平均潜伏期、波幅及上肢-下肢SSR潜伏期比和波幅比差异。结果:Hhcy组和非Hhcy组SSR潜伏期上肢分别为(1593.11±149.85)ms、(1539.75±149.22)ms(P>0.05);下肢分别为(2795.86±415.24)ms、(2617.93±327.61)ms(P<0.05)。Hhcy组和非Hhcy组SSR波幅上肢分别为(1.03±0.38)mV、(1.22±0.30)mV(P<0.01);下肢分别为(0.28±0.17)mV、(0.38±0.15)mV(P<0.01)。2组上肢-下肢SSR波幅比Hhcy组较非Hhcy组增高(P<0.01),而同侧上肢-下肢SSR潜伏期比2组差异无统计学意义。结论:Hhcy可以加重2型DM交感神经损害程度,且有长度依赖性特点,而SSR检测是简单可行的手段。Objective： To investigate effects of hyperhomocysteinemia（Hhcy）on the sympathetic nervous function in pa- tients with type 2 diabetic mellitus（DM）. Methods： Forty-four patients with type 2 DM were divided in[o two groups, Hhcy group （n=22） and non Hhcy （Nhhcy） group （n=22）. Values of sympathetic skin reflex（SSR） were detected by Keypoint.net elec- tromyogram in four limbs of all patients, and average latencies, amplitudes and ratios of upper to lower limbs were compared between two groups. Results： The upper limb latencies of SSR were （1 593.11±149.85）ms and （1 539.75±149.22）ms for Hhcy group and Nhhcy group（P 〉 0.05）. The lower limb latencies of SSR were （2 795.86±415.24）ms and （2 617.93±327.61）ms for Hhcy group and Nhhcy group（P 〈 0.05）. The upper limb amplitudes of SSR were（ 1.03±0.38）mV and（ 1.22±0.30）mV in Hhcy group and Nhhcy group （P 〈 0.01）. The upper limb amplitudes of SSR were（0.28±0.17） mV and（0.38±0.15）mV in two groups （P 〈 0.01）. The SSR amplitude ratio of ipsilateral upper and lower extremities was significantly higher in Hhcy group than that of NHhcy group （P 〈 0.01）. There was no significant difference in SSR latency ratio of ipsilateral upper and lower extremities between 2 groups. Conclusion： Hhcy may increase the damage of sympathetic nervous in patients with type 2 DM, which showed features of length dependence. Detection of SSR is a simple and feasible technique.

关 键 词：高半胱氨酸 糖尿病 2型 糖尿病神经病变 交感神经系统 四肢 皮肤交感反射 

分 类 号：R589.3[医药卫生—内分泌]