心脏瓣膜钙化与颈动脉内膜中层厚度的相关性研究  

Relationship of Heart Valve Calcification and Carotid Intima Media Thickness

作　　者：贾彦青[1] 党群[2] 姚民强[2] 李永健[2] 

机构地区：[1]天津医科大学研究生院,300070 [2]天津市南开医院

出　　处：《天津医药》2012年第6期612-614,共3页Tianjin Medical Journal

摘　　要：目的:研究心脏瓣膜钙化程度与颈动脉内膜中层厚度、斑块积分的相关性。方法:用经胸多普勒超声显像仪评估426例患者心脏瓣膜钙化情况,根据瓣膜钙化诊断标准将所有患者分为无钙化组、轻度钙化组、中度钙化组和重度钙化组。比较4组间的一般资料、病史、血压、血脂,同时测量4组患者颈动脉内膜中层厚度、软斑块积分、硬斑块积分及总斑块积分。结果:4组间的年龄、性别、体质量指数、吸烟情况、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇差异无统计学意义;瓣膜钙化程度与冠心病患病率、收缩压、脉压、颈动脉内膜中层厚度、总斑块积分、硬斑块积分呈正相关(rs分别为0.546、0.628、0.512、0.802、0.628、0.544,均P<0.001),与舒张压、软斑块积分无相关性。结论:心脏瓣膜钙化程度可作为推测颈动脉内膜中层厚度、总斑块积分、硬斑块积分的一个重要指标。Objective： To investigate the relationship between the degree of heart valve calcification and carotid intima media thickness and plaque integral. Methods： The valve calcification was assessed using transthoracic Doppler ultrasound imaging in 426 patients. All patients were divided into four groups according to the diagnostic criteria, including no calcifica- tion group, mild calcification group, moderate and severe calcification group. The general information, medical history, blood pressure, blood lipids were compared between four groups. The intima media thickness, soft plaque score, hard plaque score and the total plaque score of carotid artery were also measured in patients of four groups. Results： There were no significant differences in age, gender, body mass index, smoking status, total cholesterol, triglyeerides, high density lipoprotein and low density lipoprotein between four groups. The degree of valve calcification was positively correlated with prevalence of coro- nary heart disease, systolic blood pressure, pulse pressure, carotid intima media thickness, total plaque score and hard plaque score （r = 0.546, 0.628, 0.512, 0.802, 0.628 and 0.544, P 〈 0.001）. There was no correlation between the valve calcification, diastolic blood pressure and soft plaque score. Conclusion： Heart valve calcification can he an important tool to speculate the carotid intima media thickness, total plaque score and hard plaque score.

关 键 词：心脏瓣膜疾病 钙质沉着症 颈动脉 血管内膜 动脉粥样硬化 超声检查 多普勒 彩色 

分 类 号：R587.2[医药卫生—内分泌]