应用阿立哌唑处理抗精神病药引起催乳素血症的初步研究  

Primary Study of the Efficacy of Aripiprazole for the Treatment of Hyperprolactinemia Caused by Antipsychotics

作　　者：毕波[1] 魏媛[1] 刘力[1] 秦晓霞[1] 刘盈[1] 王哲[1] 

机构地区：[1]中国医科大学附属第一医院精神医学科,辽宁沈阳110001

出　　处：《医学临床研究》2012年第4期624-626,共3页Journal of Clinical Research

摘　　要：[目的]探讨服用阿立哌唑处理抗精神病药引起的高催乳素血症的效果.[方法]对42例服用抗精神病药处于精神症状稳定期（PANSS＜60分）,但出现药源性高催乳素血症的女性精神分裂症患者,在4周内完全替换成阿立哌唑,并继续服用该药12周.临床评估包括：分别在基线、研究结束时,采用阳性与阴性症状量表（PANSS）及临床疗效总评量表（CGI-I）评定疗效、检测血清催乳素水平（PRL）;应用副反应量表（TESS）在替换前及替换后1、2、4、6、8、12周评定药物不良反应.[结果]用阿立哌唑替代抗精神病药16周后,PANSS总分、各因子分及CGI-I分与替换前差异均无统计学意义（P〉0.05）,而血清PRL水平与替换前有明显降低,不良反应患者均可耐受.[结论]对于抗精神病药引起的药源性催乳素血症,应用阿立哌唑来替代,是处理此副作用的一个有效对策.[Objective]To explore the efficacy of aripiprazole for the treatment of hyperprolactinemia caused by antipsychotics. [Methods] Forty two female patients with schizophrenia who were psychiatrically stable when taking antipsychotics（PANSS〈60）, but had drug-induced hyperprolactinemia turned to take aripiprazole within 4 weeks and continued for 12 weeks. Clinical assessments included efficacy evaluation by using positive and negative symptom scale（PANSS） and clinical global impression scale（CGI-I）, the detection of serum prolactin（PRL） and drug adverse reaction assessment by using treatment emergent symptom scale（TESS） before drug replacement and 1, 2, 4, 6, 8 and 12 weeks after drug replacement. [Results] After aripiprazole for replacing antipsychotics for 16 weeks, there was no significant difference in total PANSS scores, each factor scores and CGI-I scores between before and after replacement（ P 〉0.05）. Compared with before replacement, serum PRL levels obviously decreased after replacement. Patients could tolerate all the adverse reaction. [Conclusion] Aripiprazole for replacing antipsychotics for the treatment of hyperprolactinemia induced by antipsychotics is an effective method.

关 键 词：高催乳素血症/药物疗法 抗精神病药 

分 类 号：R589.9[医药卫生—内分泌]