不同判愈标准评估阿奇霉素治疗泌尿生殖道沙眼衣原体感染的治愈率  

Outcomes of treatment of Chlamydia trachomatis infection with azithromycin： an evaluation by different criteria

作　　者：展小飞[1] 王树椿[1] 陈昭[1] 李宜儒[1] 刘全忠[1] 

机构地区：[1]天津医科大学总医院皮肤科,天津性传播疾病研究所,300052

出　　处：《中华皮肤科杂志》2012年第6期429-430,共2页Chinese Journal of Dermatology

摘　　要：目的 探讨不同的判愈标准对阿奇霉素治疗泌尿生殖道沙眼衣原体感染（Ct）的疗效。方法 收集2006—2010年于天津医科大学总医院性病门诊确诊，用阿奇霉素治疗Ct感染的患者的完整病历，并用不同判愈标准对他们的治愈率进行分析比较。以患者症状是否消失，实验室检查结果为主要依据。疗程结束后1、5、9周分别复查衣原体，并比较疗程结束后分别复查1次，2次，3次的治愈率。结果 以症状和实验室检查为主要依据对计算治愈率差异有统计学意义，且症状与实验室检查阳性之间无明显相关性。但是复查1次和复查2次计算治愈率差异有统计学意义，而复查2次或3次对治愈率计算的差异无统计学意义。结论 阿奇霉素治疗Ct感染的判愈应以实验室检查为主，且应在疗程结束后1周及5周各复查1次。Objective To compare the recovery rates calculated according to different criteria in patients with urogenital Chlamydia trachomatis（Ct） infection after treatment with azithromycin. Methods Clinical data on outpatients who were diagnosed with urogenital Ct infection and treated with azithromycin in the sexually transmitted disease （STD） outpatient clinic of Tianjin Medical University General Hospital were retrospectively reviewed. Recovery rates were calculated according to the improvement of symptom and （or） reexamination results of Ct at 1, 5 and 9 weeks after the end of treatment. Results Significant differences were observed between the recovery rates calculated according to symptom improvement and those according to laboratory reexamination results. No obvious correlation existed between the presence of symptom and positive reexamination results. The recovery rates calculated according to the second reexamination result differed significantly from those according to the first reexamination result, but were similar to those according to the third reexamination result. Conclusions The cure of Ct infection should be determined according to laboratory test results, and two times of reexamination at 1 and 5 weeks after the final treatment are recommended.

关 键 词：沙眼衣原体 判愈 阿奇霉素 

分 类 号：R759[医药卫生—皮肤病学与性病学]