萝芙木中化学成分的研究  

Chemical constituents of Rauvolfia verticillata

作　　者：洪博[1] 李文静[1] 赵春杰[2] 

机构地区：[1]齐齐哈尔医学院,黑龙江齐齐哈尔161000 [2]沈阳药科大学,辽宁沈阳110000

出　　处：《药学学报》2012年第6期764-768,共5页Acta Pharmaceutica Sinica

摘　　要：为研究夹竹桃科植物萝芙木的化学成分及药理活性,通过硅胶、凝胶LH-20、反相开口柱等色谱方法进行分离纯化。根据化合物的理化性质和波谱数据鉴定化学结构,从氯仿层提取物中分离得到3个吲哚类生物碱和1个吖啶酮类生物碱,分别鉴定为萝芙碱B(1)、山德维辛碱(2)、萝尼生(3)和7-羟基-吖啶酮(4)。化合物1为新化合物,属于吲哚类生物碱。化合物4是吖啶酮类生物碱,为首次从萝芙木属植物中分离得到的化合物类型。本文对化合物4这一新类型的生物碱做了生物活性研究,以发掘萝芙木除降压以外其他的药理活性。The study on the Rauvolfia verticillata（Lour.） Baill.,which belongs to Apocynaceae,was carried out to look for its chemical constituents and pharmacological activity.The isolation and purification were performed by chromatography on silica gel,Sephadex LH-20 and ODS（octadecyl silane） open column.The structures of obtained compounds were elucidated on the basis of physicochemical properties and spectral analysis.Three indole alkaloids and one acridone alkaloid were isolated from chloroform layer extract and identified as ajmalicine B（1）,sandwicine（2）,raunescine（3） and 7-hydroxynoracronycine（4） separately.Ajmalicine B（1） is a new compound belonging to indole alkaloid.Compound 4 as an acridone alkaloid was a new type compound isolated from Rauvolfia genus for the first time.We also did some biological activity research on the new type compound（4） to explore other pharmacological activities in addition to antihypertensive activity.

关 键 词：夹竹桃科 萝芙木 化学成分 生物活性 

分 类 号：R284.1[医药卫生—中药学]