Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro  

作　　者：Zheng Zhang Xing Zhou Xiaowen Zhou Xiao Xu Minjing Liao Li Yan Ruohua Lv Huanmin Luo 

机构地区：[1]Department of Pharmacology,School of Medicine,Jinan University,Guangzhou 510632,Guangdong Province,China [2]Institute of Brain Science,Jinan University,Guangzhou 510632,Guangdong Province,China [3]Joint Laboratory for Brain Function and Health,Jinan University and the University of Hong Kong,Jinan University,Guangzhou 510632,Guangdong Province,China

出　　处：《Neural Regeneration Research》2012年第13期971-977,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.30672450,81173037;the National Program on Key Basic Research Project (973 Program),No.2011CB707500

摘　　要：Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate （MDHB; 2, 4, and 8 IJM）. Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression, and increased neuronal survival in a dose-dependent manner. Moreover, MDHB induced brain-derived neurotrophic factor expression. These findings suggest that MDHB has a neurotrophic effect, which may be due to its ability to increase brain-derived neurotrophic factor expression.Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate （MDHB; 2, 4, and 8 IJM）. Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression, and increased neuronal survival in a dose-dependent manner. Moreover, MDHB induced brain-derived neurotrophic factor expression. These findings suggest that MDHB has a neurotrophic effect, which may be due to its ability to increase brain-derived neurotrophic factor expression.

关 键 词：methyl 3 4-dihydroxybenzoate neurite outgrowth brain-derived neurotrophic factor neurodegenerative diseases neural regeneration 

分 类 号：Q424[生物学—神经生物学] Q813.11[生物学—生理学]