Evaluation of the Genotoxicity of Polymeric Microparticles Containing Ametryn Herbicide  

作　　者：Renata de Lima Leandro O. Feitosa Renato Grillo Anderson E.S. Pereira Leonardo FernandesFraceto 

机构地区：[1]Department of Biotechnology, University of Sorocaba, Sorocaba 18023-000, Brazil [2]Federal University of Sao Carlos, Sorocaba 18052-780, Brazil [3]Department of Environmental Engineering, UNESP-Univ. Estadual Paulista, Sorocaba 18087-180, Brazil [4]Department of Biochemistry, Institute of Biology, UNICAMP, Campinas 18083-862, Brazil

出　　处：《Journal of Environmental Science and Engineering(A)》2012年第4期553-565,共13页环境科学与工程（A）

摘　　要：Agrochemicals have been used throughout the ages to eradicate weeds and pests. Use of agrochemicals is now commonplace, serving as an aid in farming procedures and contributing to greater agricultural production. However, the indiscriminate use of agrochemicals is a cause for concern because they can exert toxic effects on the environment and hence on living beings. This work involved a genotoxic analysis of controlled release formulations of the herbicide ametryn encapsulated in microspheres of poly（hydroxybutyrate） and poly（hydroxybutyrate-co^valerate）. Genotoxicity was analyzed using cytogenetic, micronucleus, comet and Allium cepa assays, as well as molecular analysis. The results showed that the rate of chromosome breakdown caused by unencapsulated ametryn was much higher than that caused by ametryn encapsulated in the polymer microspheres （p 〈 0.05）. This indicates that controlled release delivery systems employing the polymer formulations should be significantly safer for the environment and for living beings.

关 键 词：AMETRYN controlled release environmental chemistry genotoxicity. 

分 类 号：S482.4[农业科学—农药学] TQ325.7[农业科学—植物保护]