Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity  

作　　者：Chen Zhao Li Qit Luyi Wu Tao Yi Huangan Wu Xinxin Guo Cili Zhou Huirong Liu Xiaomei Wang 

机构地区：[1]Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China [2]Key Unit of Acupuncture-Moxibustion and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030,China [3]Qigong Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China

出　　处：《Neural Regeneration Research》2012年第15期1145-1150,共6页中国神经再生研究（英文版）

基　　金：supported by the National Basic Research Program of China (973 Program) (No. 2009CB522900);Nanjing University of Chinese Medicine, Key Laboratory of Acupuncture Combined with Medication (No. KJA200914);the National Natural Science Foundation of China (No. 30973783)

摘　　要：Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu （ST25） point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceralSuspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu （ST25） point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral

关 键 词：suspended moxibustion chronic visceral hypersensitivity irritable bowel syndrome prokineticin 1 prokineticin receptor 1 spinal cord neural regeneration 

分 类 号：Q438[生物学—生理学] S858.966[农业科学—临床兽医学]