水通道蛋白-1、5介导的肺损伤的研究进展  

Advances of the lung injury mediated by aquaporin 1. 5

作　　者：钟薇薇[1] 李元海[1] 

机构地区：[1]安徽医科大学第一附属医院,合肥230022

出　　处：《国际麻醉学与复苏杂志》2012年第6期426-430,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：背景水通道蛋（aquaporin，AQP）是一类高效率跨膜转运水分子的蛋白通道家族，参与诸多组织器官中的水转运及细胞内外的水平衡。现已证实有6种AQP（AQP1、3,4、5、8、9）分布于肺组织，有大量研究证明AQP1、5在肺水转运中的作用尤为重要。目的通过对AQP1、5在急性肺损伤（acutelunginjury，Au）中的作用的研究来指导临床实践。内容探讨AQP1、5在ALI中的作用及调控机制。趋势随着对AQP1、5作用机制研究的不断深入，给相关疾病的防治带来了希望。Background Aquaporins（AQP）, a kind of high efficiency family of transmembrane water channels , participate in the water transport of kinds of tissues and organs, and they also maintain intraceUular ＆ extracellular water balance. Nowadays, it is showed that there are six aquaporins in the lung tissue, and that AQP1 and AQP5 might play an important role in the water transport of the lung tissue. Objective It is of great clinical significance to clarify the mechanisms of AQP1, 5 mediated acute lung injury （ALI）. Content This review mainly discusses the lung injury mediated by AQP1, 5. Trend With the progresses of the research, it will develop some new clinical prevention and treatment strategys of lung diseases.

关 键 词：水通道蛋白 肺损伤 水平衡 

分 类 号：R563[医药卫生—呼吸系统]