中药夏桑菊复方提取物中的黄酮类成分研究  

Research of flavonoids in the extract of traditional Chinese medicine Xiasangju

作　　者：刘伟国[1] 苏乐群[1] 郭秀丽[2] 

机构地区：[1]山东省千佛山医院药剂科,济南250014 [2]山东大学药学院药理学教研室,济南250012

出　　处：《国际中医中药杂志》2012年第6期522-524,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨中药夏桑菊复方提取物中的化学成分。方法利用乙醇提取，不同有机溶剂萃取，硅胶与凝胶柱色谱分离纯化技术进行化合物的分离，根据理化性质和波谱数据进行结构鉴定。结果从乙酸乙酯萃取物中分离得到6个黄酮类成分，分别为山奈酚（Ⅰ）、槲皮素（Ⅱ）、木犀草素（Ⅲ）、槲皮素-3-O-β-D．葡萄糖苷（Ⅳ）、木犀草素-7-O-β-D-葡萄糖苷（Ⅴ）和芸香苷（Ⅵ）。结论所得到的化合物均为首次从夏桑菊复方中分离得到。Objective To study the chemical composition of traditional Chinese medicine Xiasangju compound extract. Methods The ethanol extract of different organic solvent extraction, silica gel column chromatography, chromatography separation and purification technology for the separation of compounds, the structures were elucidated by chemical and spectral data. Results Six flavonoid components were isolated from the ethyl acetate extract, respectively, kaempferol （Ⅰ）, quercetin （ Ⅱ ）, luteolin （Ⅲ）, quercetin-3-O-β-D-glucoside （Ⅳ）, luteolin-7-O-β-D-glucoside （Ⅴ） and rutin （Ⅵ）. Conclusion The obtained compounds were isolated from compound Xiasangju for the first time.

关 键 词：夏桑菊复方 化学成分 黄酮 

分 类 号：R284[医药卫生—中药学]