腰椎放疗后急性期微循环改变的磁共振灌注成像  

Acute-stage microcirculation changes of lumbar spine vertebral bone marrow after radiotherapy with magnetic resonance perfusion-weighted imaging

作　　者：谢锋[1] 潘诗农[1] 王丰哲[1] 富西湖[1] 刘楠[1] 郭启勇[1] 

机构地区：[1]中国医科大学附属盛京医院放射科,辽宁省沈阳市110004

出　　处：《中国组织工程研究》2012年第22期4080-4083,共4页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省教育厅2009年度高等学校科研项目计划(2009T098)~~

摘　　要：背景:采用磁共振灌注成像来研究腰椎放疗后短期内微循环改变的情况,对于研究腰椎微循环特点、制定放疗计划、判断疾病预后等具有重要意义。目的:采用磁共振灌注成像的方法,观察兔腰椎放疗后的急性期微循环改变。方法:将15只家兔随机等分为3组,分别进行腰椎动态对比增强磁共振扫描,24h后进行腰椎局部放疗。在3组家兔腰椎部分分别进行500cGy,1000cGy和1500cGy不同剂量的放疗。放疗7d后,对3组家兔再次进行腰椎动态对比增强磁共振扫描。运用时间-强度曲线分析最大增强值、峰值增强率和增强斜率的变化。结果与结论:500cGy组放疗后最大增强值增加(P<0.05);1000cGy组最大增强值和增强斜率增加(P<0.05);1500cGy组最大增强值、峰值增强率及增强斜率均增加(P<0.05)。结果证实,采用动态对比增强磁共振灌注成像可观察到放疗后家兔腰椎急性期微循环灌注增加,呈剂量依赖性。BACKGROUND： The study of the shortly change of microcirculation after lumbar radiotherapy using magnetic resonance perfusion-weighted imaging is significant to research lumbar micro-cycle characteristics, the development of radiation treatment planning, as well as to determine the disease prognosis. OBJECTIVE： To investigate the acute-stage microcirculation changes of lumbar spine vertebral bone marrow in rabbit after radiotherapy with magnetic resonance perfusion-weighted imaging. METHODS： Fifteen rabbits were divided into 3 groups and underwent dynamic contrast enhanced magnetic resonance imaging of the lumbar spine. After 24 hours, local radiotherapy of the lumbar spine was performed, each rabbit underwent radiotherapy on lumbar spine by different X-ray doses （500 cGy, 1 000 cGy, 1 500 cGy）. Seven days after the radiotherapy, each subject re-underwent dynamic contrast enhanced magnetic resonance imaging of the lumbar spine. The changes of the maximum enhancement value, peak enhancement rate and the wash-in rate were analyzed with the time-intensity curve. RESULTS AND CONCLUSION： The maximum enhancement value in the group with 500 cGy was increased after radiotherapy （P 〈 0.05）. The maximum enhancement value and the wash-in rate in the group with 1 000 cGy were increased after radiotherapy （P 〈 0.05）. The maximum enhancement value, peak enhancement rate and the wash-in rate in the group with 1 500 cGy were increased after radiotherapy （P 〈 0.05）. It can be observed using dynamic contrast-enhanced magnetic resonance perfusion imaging that the acute-stage changes of the microcirculation of rabbit lumbar spine vertebral bone marrow is ascended after radiotherapy, and in a dose-dependent manner.

关 键 词：微循环 腰椎 放疗 家兔 急性期 磁共振灌注成像 最大增强值 峰值增强率 增强斜率 

分 类 号：R318[医药卫生—生物医学工程]