白细胞介素-21在慢性乙型肝炎病毒感染中的作用  

The roles of interleukin-21 in chronic hepatitis B virus infection

作　　者：马世武[1,2] 黄璇[2] 侯金林[2] 

机构地区：[1]成都军区昆明总医院感染科,云南昆明650032 [2]南方医科大学南方医院感染内科,广东广州510515

出　　处：《中国病毒病杂志》2012年第3期169-172,共4页Chinese Journal of Viral Diseases

基　　金：国家自然科学基金(30730082;30901271);国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10002-003)

摘　　要：细胞因子网络是炎症及免疫应答反应的重要效应因子,特别对于获得性免疫网络的构成起到了重要的作用。近年来,以细胞因子为切入点,探讨慢性感染性疾病的发病机制、诊断、预防和治疗策略成为重要的研究方向,如白细胞介素（IL）-28B在丙型肝炎（丙肝）抗病毒治疗[1]、IL-17在重度肝。Cytokines play important roles in initiating and shaping pathologic responses in chronic viral infection.Recent studies indicate that interleukin（IL）-21,a cytokine produced mostly by activated CD4＋ T cells and natural killer cells,regulates activation,proliferation,and survival of both CD4＋ T cells and B cells,modulates the functional activity of CD8＋ T cells and NK cells and controls the differentiation of inducible Treg and counteracts their suppressive properties on effector T cells.High level of IL-21 is correlated with HBV replication repression and HBeAg sero-conversion in chronic hepatitis B.This review focuses on the critical roles of IL-21 in chronic hepatitis B virus（HBV） infection including HBV-related acute-on-chronic liver failure.

关 键 词：病毒性肝炎 乙型 乙型肝炎病毒 白细胞介素-21 

分 类 号：R512.62[医药卫生—内科学]