持续气道正压通气治疗阻塞型睡眠呼吸暂停低通气综合征合并2型糖尿病的疗效观察  

Effects of continuous positive airway pressure therapy on patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes

作　　者：刘琼玲[1] 林琳[1] 李雪洁[1] 吴伊茄[1] 

机构地区：[1]广东医学院护理学院,广东东莞523800

出　　处：《广东医学院学报》2012年第1期17-19,共3页Journal of Guangdong Medical College

基　　金：2009年广东省护理学会基金资助项目(No.B2009015)

摘　　要：目的通过观察持续气道正压通气(CPAP)治疗对合并2型糖尿病(T2DM)的阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者的胰岛素抵抗(IR)的影响。方法 46例合并T2DM的OSAHS患者随机分为2组,对照组(22例)行保守治疗,而实验组(24例)加用CPAP治疗。观察所有患者治疗前及治疗后1、3、6个月的临床指标变化,采用稳态模式评估(HOMA)指数评价IR。结果实验组患者治疗1个月后,其最低SaO 2水平明显高于治疗前及同一时段的对照组(P<0.01);治疗3个月后,其呼吸暂停低通气指数明显低于治疗前及同一时段的对照组(P<0.01);治疗6个月后,其空腹胰岛素及HOMA水平明显低于治疗前及同一时段的对照组(P<0.01)。结论长期CPAP治疗可显著改善合并T2DM的OSAHS患者的IR。Objective To observe the effects of continuous positive airway pressure（CPAP） therapy on insulin resistance（IR） of patients with obstructive sleep apnea hypopnea syndrome（OSAHS） and type 2 diabetes.Methods Forty-six patients with OSAHS and type 2 diabetes were randomly divided into two groups： control group（n=22） received the conventional treatment,while observation group（n=24） accepted additional CPAP therapy.IR was evaluated with homeostasis model assessment（HOMA） index.Clinical parameters of all patients were measured before and 1,3 and 6 months after treatment.Results Compared with pretreatment and control group at same time points,the minimal SaO2 level increased 1 month post treatment（P0.01）,apnea hypopnea index（AHI） decreased 3 months post treatment（P0.01）,and fasting insulin level and HOMA index reduced 6 months post treatment（P0.01） in observation group.Conclusion Long-term CPAP treatment can obviously improve the IR in patients with OSAHS and type 2 diabetes.

关 键 词：睡眠呼吸暂停低通气综合征 持续气道正压通气 胰岛素抵抗 2型糖尿病 

分 类 号：R441.8[医药卫生—诊断学]