慢性马兜铃酸肾病患者血清TGF-β1、BMP-7的改变  

Changes of serum TGF-β1 、BMP-7 in patients with chronic aristolochic Acid Nephropathy

作　　者：牛效清[1] 陈楠[1] 刘中柱[1] 刘艳姝[1] 张浩[1] 

机构地区：[1]佳木斯大学附属第一医院肾内科,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2012年第2期34-35,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨慢性马兜铃酸肾病(CAAN)患者血清转化生长因子-β1(TGF-β1)、骨形态发生蛋白-7(BMP-7)的变化及临床意义。方法:采用ELISA法测定30例CAAN患者血清TGF-β1及BMP-7水平,并用20例正常健康人作对照。结果:与对照组相比病例组TGF-β1明显增高(P<0.05),BMP-7明显降低(P<0.05)。TGF-β1与BMP-7呈负相关(r=-0.379,P<0.05)。结论:TGF-β1、BMP-7二者的表达水平及其相互间调节作用是慢性马兜铃酸肾病发病机制中的重要环节。Objective：To explore the change of serum TGF-β1 and BMP-7 in patients with chronic aristolochic acid nephropathy（CAAN） and its clinical significance. Methods： The level of TGF-β1 、BMP-7 of the serum from 30 CAAN patients was determined by ELISA.And 20 healthy adults were selected as a control group.Results： The concentration of TGF-β1 in serum in CAAN patients was significantly higher than that in the control group（P0.05）.The BMP-7 in serum in CAAN patients was significantly lower than that in control group（P0.05）.For all patients,there was a significant negative relation between the TGF-β1 and BMP-7 level（r=-0.463,P0.05）.Conclusion：The expression of TGF-β1 and BMP-7 as well as its mutual regulation is an important stage of CAAN pathogenesis.

关 键 词：慢性AAN 转化生长因子-Β1 骨形态发生蛋白-7 

分 类 号：R692[医药卫生—泌尿科学]