2型糖尿病患者颈动脉内中膜厚度与肾小球滤过率的相关性分析  

Relationship between carotid intima-media thickness and glomerular filtration rate in type 2 diabetic patients

作　　者：贾艳坤[1] 韩丽萍[1] 谢云[1] 

机构地区：[1]天津医科大学代谢病医院糖尿病神经内科,卫生部激素与发育重点实验室,300070

出　　处：《中国糖尿病杂志》2012年第6期428-430,共3页Chinese Journal of Diabetes

摘　　要：目的探讨T2DM患者颈动脉内中膜厚度(cIMT)与肾小球滤过率(GFR)的相关性。方法随机选取年龄>45岁的血压控制在140/90mmHg以下的T2DM患者143例,以cIMT 0.9mm为标准将其分为cIMT<0.9mm(IMT正常组)和cIMT≥0.9mm(IMT增厚组),比较两组间年龄、病程、早期肾病(MAU)所占比例、GFR及各项生化指标的差异。结果 IMT增厚组的年龄、糖尿病病程、MAU所占比例明显高于IMT正常组,而GFR则明显低于IMT正常组(P<0.05)。多元逐步回归分析显示cIMT与年龄、糖尿病病程呈正相关,而与GFR呈负相关。结论随着动脉硬化的不断进展,GFR呈不断下降趋势且独立于传统的心血管危险因素参与早期动脉硬化的发生与发展。Objective To investigate the correlation between carotid intima-media thickness （cIMT） and glomerular filtration rate （GFR） in type 2 diabetic patients. Methods 143 patients whose age is above 45 years were selected and the patients＇ blood pressure should be controlled below 140/90 mmHg. The patients were divided into two groups： the normal group （cIMT〈0. 9 mm） and the thick group （cIMT〈0. 9 mm） by the cut level of cIMT 0. 9 mm. The age, duration, MAU frequency, GFR and biochemical indexes were compared between them. Results clMT thick group＇ s age, duration and MAU frequency were much higher than those of cIMT normal group, and the GFR of the thick group was much lower than that of the normal group （P〈0.05）. No statistical difference was found in biochemical indexes such as fasting glucose and lipids between two groups. Multiple stepwise regression analysis showed clMT had a positive correlation with age, duration, and had a negative correlation with eGFR. Conclusions With the development of the atherosclerosis, GFR gradually decreases and contributes to the occurance and development of early-stage atherosclerosis.

关 键 词：糖尿病 2型 颈动脉内中膜厚度 肾小球滤过率 

分 类 号：R587.1[医药卫生—内分泌]