不同剂量吡格列酮对STZ糖尿病大鼠体内氧化应激的影响  

Effect of different dosages of piogitazone on the level of oxidative stress in STZ-induced diabetic rats

作　　者：王月芬[1] 邢燕[1] 叶山东[1] 

机构地区：[1]安徽医科大学附属省立医院,合肥230001

出　　处：《中国糖尿病杂志》2012年第6期466-468,共3页Chinese Journal of Diabetes

基　　金：安徽省自然科学基金(070413255X);安徽省人才开发基金资助(2008Z048)

摘　　要：目的探讨不同剂量吡格列酮(PIO)对STZ诱导的DM大鼠体内氧化应激的影响。方法 STZ腹腔注射建立DM大鼠模型。成模DM大鼠随机分为模型组和不同剂量PIO组,并设正常对照(NC)组,4周和8周时腹主动脉取血检测血清丙二醛(MDA)水平和超氧化物歧化酶(SOD)活性。结果 4周时,模型组较NC组MDA含量显著升高,SOD活性显著下降(P均<0.01);PIO各组较NC组差异无统计学意义(P>0.05)。8周时,模型组、PIO各组较NC组MDA含量显著升高,SOD活性显著下降(P均<0.01),PIO 20mg.kg-1.d-1和30mg.kg-1.d-1组较模型组MDA含量显著降低,SOD活性显著升高(P均<0.01),PIO 10mg.kg-1.d-1组较模型组差异无统计学意义(P>0.05)。结论 PIO可减轻DM大鼠体内氧化应激,且该作用具有一定的剂量依赖性。Objective To investigate the effect of different dosages of pioglitazone （PIO） on the oxidative stress in STZ-indueed diabetic rats. Methods Diabetic models were established by a peritoneal injection of streptozotocin （STZ）. All the diabetic rats were randomized into model group and PIO different dosage groups. The healthy rats served as a normal control group. At the 4th week and 8th week, the abdominal aortic blood was obtained for measuring serum superoxide dismutase （SOD） activity and malondialdehyde （MDA） level. Results At the 4th week, the MDA level increased and the SOD activity decreased significantly in the model group, compared with the NC group （P〈0. 01）, but those in the PIO groups were not statistically different from those in the NC group （P〈0. 05）. At the 8th week, the MDA level increased and the SOD activity decreased significantly in the model group and all the PIO groups, compared with the NC group （P〈0. 01）. The MDA level decreased and the SOD activity increased significantly in the PIO 20 mg·kg^-1·d^-1 and 30 mg·kg^-1·d^-1 groups, compared with the NC group （P〈0. 01）. There was no statistical difference between the PIO 10 mg·kg^-1·d^-1group and the model group （P〈0. 05）. Conclusion Piogitazone can alleviate oxidative stress in vivo with a dose dependent manner in STZ-indueed diabetic rats.

关 键 词：超氧化物歧化酶 丙二醛 氧化应激 吡格列酮 

分 类 号：R587.1[医药卫生—内分泌]