2008-2010年金黄色葡萄球菌的耐药性变迁  

Variation of drug resistance of Staphyloccous aureus during 2008-2010

作　　者：张正银[1] 窦蓉[1] 周强华[1] 孙晴[1] 

机构地区：[1]上海市长宁区中心医院检验科,上海200336

出　　处：《中华医院感染学杂志》2012年第11期2412-2414,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解临床分离金黄色葡萄球菌(SAU)的感染特征及耐药性变迁,为临床合理使用抗菌药物提供依据。方法对医院2008-2010年临床标本中分离的SAU进行回顾性分析。结果共获得1198株SAU,其中来源于呼吸道943株,占78.7%,分泌物149株,占12.4%,尿液56株,占4.7%;SAU中耐甲氧西林金黄色葡萄球菌2008-2010年检出率分别84.1%、84.7%、84.0%;对β-内酰胺类、氨基糖苷类、氟喹诺酮类、大环内酯类、四环素类及克林霉素的耐药率均较高,均>75.0%,对磺胺甲噁唑/甲氧苄啶部分敏感,耐药率<50.0%;对利福平较敏感,耐药率8.9%～16.9%,对万古霉素、利奈唑胺无耐药。结论 SAU耐药严重,应加大监控力度,预防MRSA感染的发生、传播及流行。OBJECTIVE To investigate the infection characteristics and antimicrobial resistance of clinically isolated Staphyloccous aureus,providing reference for antibiotics use in clinical practice.METHODS A retrospective analysis was carried out of S.aureus isolates from various clinical specimens from Jan 2008 to Dec 2010.RESULTS A total of 1198 strains of S.aureus were obtained,of which 943 strains were isolated from respiratory tract,accounting for 78.7%;149 strains were isolated from secretions,accounting for 12.4%;56 strains were isolated from urine,accounting for 4.7%.Meticillin-resistant S.aureus（MRSA） accounted for 84.1% in 2008;84.7% in 2009;84.0% in 2010,respectively.The resistance rates of S.aureus to β-lactams,aminoglycosides,fluoroquinolones,macrolides,tetracylines and lincosamides were relatively high,all above 75.0%.The resistance rates to sulfamethoxazole/trimethoprim were below 50.0%,and to rifampicin was 8.9%-16.9%.Strain resistant to vancomycin or linezolid was not found.CONCLUSION Drug resistance of S.aureus is relatively serious,especially MRSA.The monitoring should be strengthened to prevent the MRSA infection,spread and prevalence.

关 键 词：金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 耐药率 

分 类 号：R378.11[医药卫生—病原生物学]