双路独立可调离子源用于分子质量的准确测定  

Independent Adjustable Ion Source for Accurate Mass Determination

作　　者：马力坡[1] 王光辉[2] 辛斌[2] 陈义[1,3,2] 

机构地区：[1]中国科学院化学研究所活体分析化学院重点实验室 [2]中国科学院北京质谱中心,北京100190 [3]北京分子科学国家实验室

出　　处：《高等学校化学学报》2012年第6期1167-1171,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21027003)资助

摘　　要：研制了一种可移动的大气环境电喷雾离子化源,用其构建了位置可调的双路离子源,能分路、同时注入待测样品与标准.将其与四极杆-飞行时间(Q-TOF)质谱联用进行研究,证明其能独立、动态调节待测样品和标准的质谱信号或峰高比例,适于有限样品质量的准确测定,质量误差一般<2×10-6,最大不超过5×10-6.Ambient electrospray guns were fabricated. any ambient inlet of a mass spectrometer（MS） such as They worked independently and could easily be set at Quadrupole-Time of Flight（Q-TOF） MS. By adjusting the distance and/or angle of their nozzles to the inlet, the signal intensity was dynamically regulated without any change of sample concentration and stop of the equipment. Using two of such guns, sample and calibrants were sprayed, ionized and introduced into the mass spectrometry separately but simultaneously. The peak ratio of sample to calibriant was dynamically adjusted to about 1：1 and high accurate molecular mass was measured, with an error of -2.7×10^-6 which was -2. 9×10^-6 by common internal calibrating determination. The method has been validated by a long time（ 〉20 months） measure of different samples（〉100） from various laboratories. The overall mass errors were kept within ＋5 ×10^-6. It can be concluded that the method is facile, flexible, time- and cost-effective, and universally applicable

关 键 词：大气环境电喷雾离子枪 可调双离子源质谱 准确质量测定 

分 类 号：O657.63[理学—分析化学]