黄酮类药物与氯金酸的作用及其分析应用  

Redox of Flavonoids with Chlorauric Acid and Its Analytical Application

作　　者：王慧娟[1] 李春梅[1] 刘跃[1] 李原芳[1] 

机构地区：[1]发光与实时分析教育部重点实验室,西南大学化学化工学院,重庆400715

出　　处：《高等学校化学学报》2012年第6期1172-1176,共5页Chemical Journal of Chinese Universities

基　　金：国家“重大新药创制”科技重大专项(批准号:2010ZX09401-306-1-4);国家自然科学基金(批准号:21175109);重庆市自然科学基金(批准号:2010AA5015)资助

摘　　要：将4种黄酮类药物染料木素、木犀草素、大豆素及柚皮素与氯金酸在不同酸度条件下反应形成金纳米颗粒.研究发现,生成的金纳米颗粒的等离子体共振吸收信号与4种黄酮类药物的浓度呈线性关系,从而建立了这4种典型黄酮类药物的测定方法.分析了黄酮类药物的分子结构并利用Materials-studio 4.0软件计算了各原子的电子云密度分布.结果表明,4种黄酮类药物与氯金酸作用的适宜酸度与黄酮类化合物结构中的酚羟基数和碱性氧的电子云密度分布有关.Four flavonoids including genistein, luteolin, daidzein and naringenin can reduce HAuC14 to form gold nanoparticles in different acidity. There are good linear correlations between the signal of plasmon resonance absorption of gold nanoparticles and the concentration of four flavonoids. Thus, we developed a method to detect these four flavonoids respectively. By analyzing the molecular structure and calculating the electron cloud density distribution of the atoms using Materials-studio 4. 0, we found that suitable pH for the reaction of different flavonoids and HAuC14 was related to the number of phenolic hydroxyl group of flavonoid and electron cloud density distribution of alkaline oxygen atoms.

关 键 词：染料木素 木犀草素 大豆素 柚皮素 金纳米颗粒 等离子体共振吸收 

分 类 号：O657[理学—分析化学]