毛姜花中的细胞毒活性二萜成分  

Cytotoxic Labdane-type Diterpenes and Diterpene Derivative from Hedychium villosum

作　　者：赵庆[1] 邹澄[2] 余琴[2] 赵声定[1] 何红平[3] 郝小江[3] 

机构地区：[1]云南中医学院中药学院,昆明650500 [2]昆明医学院药学院,昆明650500 [3]中国科学院昆明植物研究所植物化学西部国家重点实验室,昆明650204

出　　处：《高等学校化学学报》2012年第6期1220-1225,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:81060262)资助

摘　　要：从毛姜花(Hedychium villosum Wall.)中分离得到1个新二萜(1)和1个已知二萜(3).新二萜命名为Villosumcoronarin,该化合物在氯仿或甲醇溶液中发生异构化,部分转化为其差向异构体1';其平面结构经质谱、红外光谱、氢谱、碳谱及无畸变极化转移增强技术(DEPT)、氢氢相关谱(1H-1H COSY)和异核多键相关谱(HMBC)等方法确证;其相对构型由氢谱、ROESY及量化计算确证.化合物3用琼斯试剂氧化后得到化合物4.生物活性筛选结果表明,化合物1对人白血病细胞株(HL-60)和肝癌细胞株(SMMC-7721)具有强的细胞毒活性,其活性超过阳性对照顺铂(DDP).化合物4对HL-60和SMMC-7721细胞具有显著的细胞毒活性.Research on active components from rhizomes of Hedychium genus has led to isolation of some diterpenes with significant cytotoxic activities against Chinese hamster V-79 cells, KB cells, K562 ceils, A549 cells, etc.. Hedychium villosum Wall. is a perennial rhizomatous herb distributed in China and partially in Southeast Asia, which is used in the treatment of pain and inflammation. A new labdane-type diterpene （1）, methods. Compound 1 was identified as （ 11 S, 15R ） -11 -hydroxy-8 （ 17 ）, 12 （E） -labdadien-15,16-dial 11,15- hemiacetal. The known compound 3 was oxidized by Jones reagent to get diterpene derivative 4. Bioassays re- vealed that compound 1. had strong cytotoxic activity against HL-60 and SMMC-7721 cells with ICs0 values of 0. 74 and 4. 48 p, mol/L, respectively, the activities were stronger than the positive control, c/s-diaminedichlo- roplatinum（DDP）. Compound 4 also showed significant activities against HL-60 and SMMC-7721 ceils with ICs0 values of 3.15 and 9.57 mmol/L, respectively.

关 键 词：毛姜花 二萜 细胞毒活性 

分 类 号：O629[理学—有机化学]