雌激素经皮贴剂用于绝经期激素补充治疗的临床研究  

Clinical Research of Transdermal Estrogen Patches in Hormone Therapy of Menopausal Women

作　　者：殷冬梅[1] 阮祥燕[1] 闫丹[1] 杨树林[1] 刘玉兰[1] 甄洁[1] 柳顺玉[1] 王娟[1] 

机构地区：[1]首都医科大学附属北京妇产医院,北京100025

出　　处：《中国药学杂志》2012年第11期852-854,共3页Chinese Pharmaceutical Journal

基　　金：北京市自然科学基金资助项目(3082011);首都医学发展科研基金资助项目(2007-2045)

摘　　要：目的观察经皮雌激素贴剂(半水合雌二醇贴片,每贴含17-β雌二醇1.5 mg)在绝经期女性激素补充治疗方面的有效性、安全性及药物不良反应和患者的依从性。方法选择绝经期女性35例,血清卵泡成熟激素(FSH)>40 u.L-1,雌二醇(E2)<30 pg.mL-1,连续使用24周,每1周更换1次,每月于第4贴开始同时口服地屈孕酮10 mg,连服10 d。用药前及用药后观察Kupperman指数、测血清卵泡成熟激素、雌二醇的变化,并观察安全性指标和患者的依从性。结果用药后绝经相关症状评分Kupperman指数有明显降低,绝经期症状有显著改善,雌二醇明显升高,治疗前后肝肾功能、血糖、凝血功能均在正常范围。结论经皮肤雌激素贴剂短期用于治疗绝经期症状方面是安全和有效的。OBJECTIVE To investigate the efficacy, safety and patient compliance of transdermal estrogen patches （ 17-β estradiol,1.5 mg per patch ）in the hormone therapy in menopausal women. METHODS Thirty-five naturally menopausal women with serum levels of FSH 〉 40 u · L-I and E2 〈 30 pg · mL-] were chosen. Transdermal estrogen patches were continu- ously used once a week for 24 weeks. On the same day of using the forth patches every month, the patients began taking l0 mg dydrogesterone per day for l0 d. Menopausal complaints were evaluated, and the serum FSH and E2 levels were determined before and after the hormone therapy. The safety index and the compliance of patients were observed. RESULTS Kupperman index were decreased significantly and menopausal complaints were relieved notablely; serum E2 levels increased after therapy. Be- ibre and after treatment, liver and kidney functions, blood glucose and blood coagulation were within the normal range. CON- CLUSION Transdermal estrogen patches （ 17-β estradiol, 1.5 mg per patch ） is effective and safe for relieving menopausal symptoms at least in a short term.

关 键 词：雌激素补充治疗 经皮肤贴剂 绝经期 

分 类 号：R711.75[医药卫生—妇产科学]