壳聚糖修饰氧化铁磁性纳米颗粒的制备和性能研究  

Synthesis and characterization of chitosan modified iron oxide magnetic nanoparticles

作　　者：葛玉卿[1] 张宇[2] 顾宁[2] 

机构地区：[1]中国科学院上海微系统与信息技术研究所传感技术国家重点实验室,上海200050 [2]东南大学生物科学与医学工程学院,生物电子学国家重点实验室,江苏省生物材料与器件实验室,南京210009

出　　处：《功能材料与器件学报》2012年第2期147-152,共6页Journal of Functional Materials and Devices

基　　金：国家自然科学基金资助项目(No.31000791);国家科技部973项目(No 2011CB707505);上海市科委项目(No.09391911500;10391901600;1052nm06100;11nm0505800)

摘　　要：通过共沉淀法制备氧化铁磁性纳米颗粒,用壳聚糖对其表面进行修饰得到样品(CS@MNPs);表征其形貌结构、尺寸、表面基团、表面电荷、磁学性质和在不同介质中的稳定性等。实验结果表明,CS@MNPs具有典型的立方反尖晶石晶体结构;粒径为16.5nm;在生理(pH值7.4)条件下拥有较高的正电荷(10mV);呈现超顺磁性,对驰豫时间T1、T2,尤其是T2*具有很强的响应;在双蒸馏水和含10%新生牛血清的RPMI 1640培养液中具有良好的稳定性,具有作为磁共振造影剂的潜力。Magnetic iron oxide nanoparticles were synthesized by chemical coprecipitation and modified by chitosan（CS@MNPs）.CS@MNPs were characterized by TEM,XRD,FT-IR,VSM,zeta potential analyzer and clinical 1.5-T MR imager.It was ideally nanoparticles in medical applications own to their smaller size（16.5nm）,positive surface charge（pH 7.4）,superparamagnetic behaviour.Its relaxation time T1,T2,in particular T＊2 had a strong response by using a clinical 1.5-T MRI imager.It was well-dispersion in double distilled water and RPMI 1640 containing 10% FCS.It has demonstrated the potential to be as a MRI contrast agent.

关 键 词：氧化铁磁性纳米颗粒 壳聚糖 表面修饰 磁共振造影剂 

分 类 号：O646[理学—物理化学]