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机构地区:[1]广西壮族自治区南丹县人民医院检验科,547200 [2]广西壮族自治区南丹县妇幼保健院检验科,547200 [3]广西壮族自治区南宁市人口和计划生育服务中心,530022 [4]广西壮族自治区南宁市第四人民医院检验科,530023
出 处:《检验医学与临床》2012年第9期1027-1028,共2页Laboratory Medicine and Clinic
基 金:广西区卫生厅课题(Z.2010014);国家科技支撑计划项目课题资助项目(2006BAI05A02)
摘 要:目的总结和分析本院新生儿脐带血葡萄糖-6-磷酸脱氢酶(G6PD)活性检测结果,为新生儿G6PD缺乏症筛查提供依据和参考。探讨脐带血G6PD检测在新生儿黄疸鉴别诊断及早期防治中的临床意义。方法新生儿出生后立即取脐带血置于乙二胺四乙酸抗凝真空管,采用全自动生化分析仪进行定量检测,低于参考值为缺乏。结果 G6PD缺乏率为10.10%,其中男婴为12.00%,女婴为7.77%,男性缺乏率高于女性缺乏率。结论采用新生儿脐带血检测G6PD活性,取材方便、简单,能有效、早期筛查出G6PD缺乏患儿,脐带血G6PD活性检测在新生儿黄疸鉴别诊断及早期治疗中有重要临床价值。Objective To summarize and analyze the results of 6-phosphate dehydrogenase(G6PD) activity in the neonatal cord blood,to provide a basis and reference for the neonatal screening of G6PD deficiency.To approach the clinical significance of G6PD testing of cord blood for the differential diagnosis of neonatal jaundice and prevention of early.Methods Umbilical cord blood was taken immediately after birth,and then put into the anticoagulant vacuum tube with ETDA,using automatic biochemical analyzer for quantitative testing.If it is below the reference,the value is taken as lacking.Results The G6PD lack rate was 10.10%,in which it was 12.00% for boy,7.77% for the girls.Conclusion It is convenient and simple for early screening of G6PD deficiency in children using the detection of G6PD activity of umbilical cord blood,which is detected in the differential diagnosis of neonatal jaundice and early treatment has important clinical value.
关 键 词:葡萄糖-6-磷酸脱氢酶 脐带血 新生儿 黄疸
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