芎麻汤及其提取物对利血平低5-HT型偏头痛模型小鼠的影响  

Effects of XiongMa decoction and its extracts on migrane model of low 5-HT induced by reserpine

作　　者：刘顶鼎[1] 郭建生[1] 曾贵荣[1] 张猛[1] 郭倩瑶[1] 侯春久[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2012年第3期17-19,共3页Journal of Hunan University of Chinese Medicine

基　　金：湖南省教育厅科研基金资助项目(06C615);湖南省研究生科研创新项目(CX2010B351)

摘　　要：目的探讨芎麻汤及其提取物对利血平所致低5-HT型偏头痛小鼠的作用机制,初步筛选芎麻汤的有效部位。方法采用皮下注射利血平(1 mg/kg)14 d复制偏头痛模型,观察芎麻汤及其提取物对利血平偏头痛小鼠体质量、凝血时间及血浆中5-HT、NO含量的影响。结果芎麻汤、芎麻汤正丁醇提取物组能增加偏头痛小鼠的体质量,调节5-HT的过度降低;芎麻汤、芎麻汤正丁醇提取物、芎麻汤乙酸乙酯提取物组能延长偏头痛小鼠的凝血时间,提高血浆中NO的含量,与模型组比较,差异具有统计学意义(P<0.01)。结论芎麻汤及其乙酸乙酯提取物、正丁醇提取物具有治疗利血平所致小鼠偏头痛的作用。Objective To study the role of Xiongma decoction and its extracts on the migrane model mouse of low 5-HT by reserpine,and screen the effective parts of XiongMa decoction preliminarily.Methods The migraine mouse model was reproduced by subcutaneous injection reserpine in a dose of 1 mg/kg once every day and lasted for 14 days.The effects of XiongMa decoction and its extracts on weight,coagulation time and 5-HT and NO content were observed.Results Compared with the modeling group,Xiongma decoction and its Butanol extract could increase mouse weight and prevent excessive decrease of 5-HT;Xiongma decoction and its Butanol extract and Ethyl acetate extract could prolong the coagulation time and improve the content of NO（P0.01）.Conclusion Xiongma decoction and its Ethyl acetate extract and Butanol extract were effective on migraine mice induced by reserpine.

关 键 词：芎麻汤及其提取物 偏头痛 小鼠 川芎 天麻 

分 类 号：R965[医药卫生—药理学]