目安眼用凝胶剂卡波姆基质组方配比研究  

Research of proportioning carbomer matrix in Muan ophthalmic gel

作　　者：何群[1] 郭畅[1] 吕毅[1] 张湘晖[2] 陈光宇[1] 王适[3] 罗怀浩[1] 

机构地区：[1]湖南中医药大学药学院中药现代化实验室,湖南长沙410208 [2]湖南中医药大学第一中医临床学院,湖南长沙410007 [3]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《湖南中医药大学学报》2012年第3期31-33,共3页Journal of Hunan University of Chinese Medicine

基　　金：湖南省科技厅资助项目(2008FJ3068);湖南省自然科学基金资助项目(11JJ3107)

摘　　要：目的筛选目安眼用凝胶剂成型最适合的基质组方,确定其最佳配比,为进一步研究奠定基础。方法以均匀性、成型性、涂展性、稠度等为评价指标,采用正交试验及等级一致性检验法,对卡波姆凝胶基质的配比进行研究。结果目安眼用凝胶卡波姆基质最佳配比为卡波姆0.8 g、甘油3.0 g和氢氧化钠0.4 g。结论确定了目安眼用凝胶卡波姆基质组方最佳配比,按该配方制备目安眼用凝胶剂,成型性最优。Objective To select the best matrix prescription for Muan ophthalmic gel moldability,determine the optimal proportioning and lay the foundation for the further research.Methods The experimental study was determined with the evaluation indexes of the uniformity,moldability,extensity and consistence,and the orthogonal design test methods and Hierarchical consistency test method.Results The best proportioning of Muan ophthalmic gel carbomer matrix is that carbomer 0.6 g,glycerol 2.0 g,sodium hydroxide 0.2 g.Conclusion The best proportioning of Muan ophthalmic gel carbomer matrix have been ensured.Preparation Muan ophthalmic gel in accordance with this matrix proportioning,its moldability is the best.

关 键 词：目安眼用凝胶剂 基质筛选 成型性 正交试验 等级一致性检验法 

分 类 号：R283.6[医药卫生—中药学]