过氧化物酶体增殖剂活化受体γ激动剂在支气管哮喘和呼吸道合胞病毒感染中的作用研究  

Effect of peroxisome proliferator-activated receptor γ agonists in bronchial asthma and respiratory syncytial virus infection

作　　者：万春杰[1] 董琳[1] 

机构地区：[1]温州医学院附属育英儿童医院呼吸科,325027

出　　处：《中华哮喘杂志（电子版）》2012年第2期50-53,共4页Chinese Journal of Asthma(Electronic Version)

基　　金：浙江省自然基金(Y2090932);温州市科技计划对外合作基金(H20080054)

摘　　要：过氧化物酶体增殖剂活化受体γ(PPARγ)是一个由配体激活的核转录因子,属于核激素受体(nuclear hormone receptor)超家族成员。被激活后,该受体除参与脂质和脂蛋白代谢,还涉及上皮细胞分化,单核/巨噬细胞等炎症细胞的活化,血管舒缩以及动脉粥样硬化形成,甚至肿瘤增殖等。本文对现有的PPARγ激动剂在支气管哮喘和呼吸道合胞病毒感染中的作用作一综述。Peroxisome proliferator-activated receptor γ（PPARγ） is a ligand-activated nuclear transcription factor,belonged to the nuclear hormone receptor superfamily.The receptor involved in lipid and lipoprotein metabolism,epithelial cells,monocytes/macrophages and other inflammatory cell activation,vasomotor and atherosclerosis formation,proliferation,and even cancer,while it is activated.In this paper,the effect of PPARγ agonists in bronchial asthma and respiratory syncytial virus infection is reviewed.

关 键 词：过氧化物酶体增殖剂活化受体γ激动剂 哮喘 呼吸道合胞病毒 

分 类 号：R544.1[医药卫生—心血管疾病]