药膳“益脾饮”对脾气虚证大鼠血液流变学及血浆TXB_2、6-keto-PGF_1α的影响  

Influence of YiPiYin on Hemorheology and TXB_2,6-Keto-PGF_1α of Plasma in Rats with Syndrome of Spleen-Qi Deficiency

作　　者：丁连翠[1] 路新国[1] 

机构地区：[1]扬州大学旅游烹饪学院,江苏扬州225127

出　　处：《西部中医药》2012年第5期33-35,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨药膳益脾饮对脾气虚证大鼠血液流变学及血浆TXB2、6-ket o-PGF1α水平的影响。方法:将48只SD大鼠随机分为6组,除空白对照组外,其余建立脾气虚模型。脾气虚模型设益脾饮高、中、低剂量干预组,四君子汤阳性对照组,模型组(以生理盐水干预),持续给药4周。第4周末分别取血测定大鼠血液流变学及血浆TXB2、6-ket o-PGF1α水平。结果:与空白对照组比较,脾气虚模型组大鼠全血高、中、低切黏度和血浆黏度、TXB2、6-ket o-PGF1α均显著升高,差异有统计学意义(P<0.01);益脾饮高、中、低剂量组及四君子汤阳性对照组的全血黏度、血浆黏度及TXB2、6-ket o-PGF1α分别与模型组比较均有所降低,差异有统计学意义(P<0.05),与空白对照组相比差异无统计学意义(P<0.05)。结论:脾气虚证大鼠存在血液高黏及易形成血栓状态,药膳益脾饮干预4周对上述指标有显著改善作用。Objective： To investigate the effects of YiPiYin on hemorheology,TXB2 and 6-keto-PGF1α of plasma in rats with syndrome of spleen-Qi deficiency.Method： Forty-eight SD rats were randomly divided into six groups. Except these in blank control group,the others were set to be the models with spleen-qi deficiency.The models with intervention were separated into high,moderate,low dose groups of YiPiYin,control group of SiJunZiTang and model group（intervened with physiological saline） for four weeks.Hemorheology,TXB2 and 6-keto-PGF1α of plasma in rats were detected by the end of forth week.Result： Compared with blank control group,high,moderate,low shear viscosity in blood,plasma viscosity,TXB2 and 6-keto-PGF1α in model group of spleen-Qideficiency raised obviously with remarkable difference（P0.01）;whole blood viscosity,plasma viscosity,TXB2 and 6-keto-PGF1α in high,moderate,low dose group of YiPiYin and positive control group of SiJunZiTang were lower than in model group with statistical meaning（P0.05）,but close to the results of blank control group without remarkable difference.Conclusion： Intervention with YiPiYin for four weeks can significantly improve blood hyperviscosity and easy formation of thrombus in rats with syndrome of spleen-Qi deficiency.

关 键 词：益脾饮 药膳 脾气虚证 血液流变学 TXB2 6-KETO-PGF1Α 动物实验 

分 类 号：R285.5[医药卫生—中药学]