中、重度负重游泳运动训练对肾上腺Cyclin D_1表达的影响  

Effect of Moderat and Heavy Weight Loaded-swimming on the Expression of Cyclin D_1 mRNA in Adrenal Body of Rats

作　　者：邓世康[1] 王航平[2] 李力燕[1] 王廷华[1] 

机构地区：[1]昆明医学院神经研究所,昆明650031 [2]云南师范大学体育学院,昆明650000

出　　处：《四川解剖学杂志》2012年第1期15-16,19,共3页Sichuan Journal of Anatomy

摘　　要：目的研究长期游泳训练后大鼠肾上腺Cyclin D1的表达变化。方法成年SD大鼠分为中度负重(占体重3%)和重度负重(占体重5%)游泳训练2组。大鼠在水槽内进行6周训练,每天1h。6周时,取肾上腺用RT-PCR检测Cyclin D1表达水平,用t检验进行统计分析。结果重度负重导致肾上腺Cyclin D1表达上调,与中度负重组比,差异有统计学意义(P<0.05)。结论重度游泳训练明显上调肾上腺Cyclin D1水平,提示Cyclin D1在游泳训练的肾上腺发挥有作用。Objective To study the effect of moderat and heavy weight loaded-swimming on the expression of Cyclin D1 mRNA in adrenal body of rats.Methods Rats were devided into middle（3% of body weight） and heavy（5% of body weight） weight loading group,then subjected swimming training for 6 weeks.The adrenal body was collected and Cyclin D1 mRNA expression was detected by RT-PCR.Results Upregulated CyclinD1 gene expression in the heavy weight loading group was found,compared with that in the moderate weight loading group（P0.05）.Conclusion This study indicate that Cyclin D1 gene expression in rats is up-regulated by heavy burden swimming training.

关 键 词：负重游泳 CYCLIND1 肾上腺 大鼠 

分 类 号：R87[医药卫生—运动医学]