二硫代氨基甲酸酯衍生物的绿色合成研究  

Highly Efficient Catalyst-Free One-Pot Synthesis of Dithiocarbamates under Solvent-Free Conditions

作　　者：倪凯伟[1] 张佩君[1] 

机构地区：[1]丽水学院化学化工系,浙江丽水323000

出　　处：《广东化工》2012年第5期307-308,312,共3页Guangdong Chemical Industry

摘　　要：文章主要研究了二硫代氨基甲酸酯衍生物的合成,将脂肪胺,CS2与α,β-不饱和羰基化合物或卤代烃在无溶剂无催化剂室温条件下,"一锅法"进行了Michael-type的加成反应,合成了二硫代氨基甲酸酯衍生物,该方法产率高,操作简单,是一种原子经济的合成方法,并可大规模的用于制药及农药方面。A highly efficient and simple synthesis of dithiocarbamates was possible based on the one-pot reaction of amines,CS2,and alkyl halides without using a catalyst under solvent-free conditions.The mild reaction conditions,high yields,and broad scope of the reaction illustrate the good synthetic utility of the method.The reaction was a highly atom-economic process for production of dithiocarbamates and can be successfully used in large quantities in the pharmaceutical or agrochemical industries.

关 键 词：二硫代氨基甲酸酯 无溶剂 二硫化碳 Α Β-不饱和羰基化合物 

分 类 号：TQ263.24[化学工程—有机化工]