低分子肝素在妊娠中晚期羊水过少治疗中的应用  

The effect of LMWH on Oligohydramnios at mid and late trimester of pregnancy

作　　者：刘珮瑜[1] 

机构地区：[1]东莞市妇幼保健院妇产科,广东省东莞523002

出　　处：《中国基层医药》2012年第8期1163-1164,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察低分子肝素用于妊娠中晚期羊水过少的治疗效果。方法90例妊娠中晚期羊水过少患者随机分为两组，均每天静脉滴注复方氨基酸500ml，5％葡萄糖注射液500ml，分次饮水（汤、牛奶、水等）共1000ml，每天左侧卧位休息不少于10h，10d为1疗程。观察组加用低分子肝素（法安明）5000U每天皮下注射1次。治疗后复查羊水指数，比较两组分娩方式、新生儿出生体质量、新生儿窒息、产后出血量等情况。结果治疗后观察组羊水指数、新生儿出生体质量明显高于对照组，剖宫产率、新生儿轻度窒息明显低于对照组（均P〈0．05）。两组新生儿重度窒息、病死率及产妇产后出血量差异均无统计学意义（均P〉0．05）。结论低分子肝素在妊娠中晚期羊水过少的治疗中可以显著增加羊水量、增加胎儿体质量，改善妊娠结局，且不增加出血风险，使用安全。Objective To detect the effect of LMWH on Oligohydramnios at mid and late trimester of pregnancy. Methods Patients were divided into two groups. Control group was given Compound amino acids 500ml,5% glucose solution 500ml by intravenous infusion and water 100Oral per oral per day, and rest in bed with left lateral position for 10 days. Test group was given the same treatments as control group, plus Flagmin 5000U by subcutaneous injection per day. Amniotic fluid index was retest after treatment. Delivery mode, newborn birth weight, neonatal asphyxia and amount of postpartum hemorrhage were compared between two groups. Results Amniotic fluid index and new- born birth weight of test group was significantly higher than control group（ P 〈0.05 ）. Cesarean section rate ,mild neo-natal asphyxia rate was significantly lower than control group（ P 〈 0. 05 ）. Severe neonatal asphyxia rate and amount of postpartum hemorrhage had no significant differences （ all P 〉 0.05 ）. Conclusion LMWH treatment could increase amniotic fluid volume and newborn birth weight on Oligohydramnios at mid and late trimester of pregnancy, improve pregnancy outcome, without increase of postpartum hemorrhage.

关 键 词：羊水过少 低分子肝素 

分 类 号：R714.2[医药卫生—妇产科学]