系统性红斑狼疮患者血浆D-二聚体水平测定及其临床意义  

Clinical significance of plasma D-dimer in patients with systemic lupus erythematosu.

作　　者：杨旭燕[1] 吴寿延[1] 

机构地区：[1]浙江省金华市中心医院肾风湿科,321000

出　　处：《临床内科杂志》2000年第3期159-160,共2页Journal of Clinical Internal Medicine

摘　　要：目的　了解系统性红斑狼疮 (SL E)患者 D-二聚体的水平测定及其临床价值。方法　用单克隆抗体乳胶凝集试验法测定 5 9例 SL E患者血浆 D-二聚体水平。结果　 (1) SL E患者血浆 D-二聚体水平较正常组显著增高 (P<0 .0 0 1) ;(2 ) SL E患者血浆 D-二聚体水平与 SL AM得分呈显著正相关 (r=0 .5 5 4,P <0 .0 0 1) ;(3) D-二聚体阳性组 SL AM得分、发生血管炎、狼疮性肾炎均明显高于阴性组 (P <0 .0 0 1)。结论　 SL E患者血浆 D-二聚体检测对判断 SL E高凝和纤溶状态、SL E疾病活动性和临床疗效具有一定的临床价值。objective To study the clinical significance of plasma D dimer in patients with systemic lupus erythematosus(SLE).Method The levels of plasma D dimer in 59 SLE patients were measured by monoclonal antibody latex agglutination test.Results The levels of D dimer in SLE patients significantly increased(P<0.001) and the levels were showed significant positive correlation with SLAM scores.SLAM score,incidenece of vasculitis and lupus nephritis in positive D dimer group group were significantly higher than those in negative D dimer group(P<0.001).Conclusion Level of plasma D dimer in SLE patients is valuable for assessment of hypercoagulative and fibrinolytic state,disease activity and therapeutic effect.

关 键 词：系统性红斑狼疮 D-二聚体 血液检验 测定 

分 类 号：R593.24[医药卫生—内科学]